Cosmos: A Spacetime Odyssey | Super/hypernova + Colors.

Physicists Have Created a New Form of Hydrogen

The most abundant element in the Universe just got interesting.

As the element that makes up 75 percent of all the mass in the Universe, and more than 90 percent of all the atoms, we’re all pretty well acquainted with hydrogen.

But the simplest and most abundant element in the Universe still has some tricks up its sleeve, because physicists have just created a never-before-seen form of hydrogen - negatively charged hydrogen clusters.

To understand what negatively charged hydrogen clusters are, you first have to wrap your head around their far more common counterparts - positively charged hydrogen clusters.

Positively charged hydrogen clusters are pretty much exactly what they sound like - positively charged clusters of a few or many hydrogen molecules.

Known simply as hydrogen ion clusters, they form at very low temperatures, and can contain as many as 100 individual atoms.

Physicists confirmed the existence of hydrogen ion clusters some 40 years ago, and while a negative counterpart to these clusters boasting large numbers of atoms were theorised, no one could figure out how to create one.

But that didn’t stop a team of physicists led by Michael Renzler from the University of Innsbruck in Austria from giving it a shot.

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Swarms of magnetic bacteria could be used to deliver drugs to tumors 

Researchers funded in part by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have recently shown that magnetic bacteria are a promising vehicle for more efficiently delivering tumor-fighting drugs. They reported their results in the August 2016 issue of Nature Nanotechnology.

Ouajdi Felfoul, Mahmood Mohammadi, Samira Taherkhani, Dominic de Lanauze, Yong Zhong Xu, Dumitru Loghin, Sherief Essa, Sylwia Jancik, Daniel Houle, Michel Lafleur, Louis Gaboury, Maryam Tabrizian, Neila Kaou, Michael Atkin, Té Vuong, Gerald Batist, Nicole Beauchemin, Danuta Radzioch, Sylvain Martel. Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nature Nanotechnology, 2016; DOI: 10.1038/nnano.2016.137

Illustration showing magnetic bacteria delivering drugs to a tumor. Credit: NanoRobotics Laboratory, Polytechnique Montreal

5 sleep disorders you didn’t know existed

Ever shouted at your partner while you slept, or woken up unable to move? From apnoea to exploding heads, here are some strange things that go bump in the night.

Sleep apnoea

A surprisingly common condition in which you stop breathing for 10 seconds or more as you sleep. The lack of oxygen causes your brain to wake you up, or pull you into much lighter sleep. Either way, it can have a profound effect on the quality of your sleep – and that of any bedfellow, as it’s often accompanied by loud snoring.

Sleep paralysis

A terrifying experience, where the body, which naturally becomes paralysed duringREM sleep, is still paralysed when you wake. You are fully conscious but cannot move or speak, sometimes for several minutes. Some people also feel as if they are choking or their chest is being crushed and they may have visual hallucinations. The condition can be exacerbated by sleep deprivation, some drugs, and disorders such as sleep apnoea.

Hypnagogic jerks

Those jumps or twitches you experience as you nod off, often accompanied by the sensation of falling. The cause remains a mystery. One idea is that you start dreaming before your body becomes paralysed. Another is that the twitches are a by-product of your nervous system relaxing as you drift off.

REM sleep disorder

If you’ve ever punched or shouted at your partner in the night, only to remember nothing next morning, you may have been in the grip of this condition. Here, the body isn’t fully paralysed during REM sleep, so people act out their dreams. Thistends to happen only with bad dreams.

Exploding head syndrome

This entails the sensation of a loud noise, like an exploding bomb or a gunshot, as you drift off or wake up. It affects about 1 in 10 of us and it tends to start around age 50. Nobody knows what causes it– perhaps physical changes in the middle ear, or a minor seizure in the brain’s temporal lobe. Despite its name, the condition is harmless.

Image Credit: Toby Leigh

Source: New Scientist (By Catherine de Lange)

Today is World Blood Donor Day – here’s a look at some blood chemistry! More info/high-res image: http://wp.me/s4aPLT-blood

Using the Power of Space to Fight Cancer

From cancer research to DNA sequencing, the International Space Space is proving to be an ideal platform for medical research. But new techniques in fighting cancer are not confined to research on the space station. Increasingly, artificial intelligence is helping to “read” large datasets. And for the past 15 years, these big data techniques pioneered by our Jet Propulsion Laboratory have been revolutionizing biomedical research.

Microgravity Research on Space Station

On Earth, scientists have devised several laboratory methods to mimic normal cellular behavior, but none of them work exactly the way the body does. Beginning more than 40 years ago aboard Skylab and continuing today aboard the space station, we and our partners have conducted research in the microgravity of space.  In this environment, in vitro cells arrange themselves into three-dimensional groupings, or aggregates. These aggregates more closely resemble what actually occurs in the human body. Cells in microgravity also tend to clump together more easily, and they experience reduced fluid shear stress – a type of turbulence that can affect their behavior. The development of 3D structure and enhanced cell differentiation seen in microgravity may help scientists study cell behavior and cancer development in models that behave more like tissues in the human body.

In addition, using the distinctive microgravity environment aboard the station, researchers are making further advancements in cancer therapy. The process of microencapsulation was investigated aboard the space station in an effort to improve the Earth-based technology. Microencapsulation is a technique that creates tiny, liquid-filled, biodegradable micro-balloons that can serve as delivery systems for various compounds, including specific combinations of concentrated anti-tumor drugs. For decades, scientists and clinicians have looked for the best ways to deliver these micro-balloons, or microcapsules, directly to specific treatment sites within a cancer patient, a process that has the potential to revolutionize cancer treatment.

A team of scientists at Johnson Space Center used the station as a tool to advance an Earth-based microencapsulation system, known as the Microencapsulation Electrostatic Processing System-II (MEPS-II), as a way to make more effective microcapsules. The team leveraged fluid behavior in microgravity to develop a new technique for making these microcapsules that would be more effective on Earth. In space, microgravity brought together two liquids incapable of mixing on Earth (80 percent water and 20 percent oil) in such a way that spontaneously caused liquid-filled microcapsules to form as spherical, tiny, liquid-filled bubbles surrounded by a thin, semipermeable, outer membrane. After studying these microcapsules on Earth, the team was able to develop a system to make more of the space-like microcapsules on Earth and are now performing activities leading to FDA approval for use in cancer treatment.  

In addition, the ISS National Laboratory managed by the Center for the Advancement of Science in Space (CASIS) has also sponsored cancer-related investigations.  An example of that is an investigation conducted by the commercial company Eli Lilly that seeks to crystallize a human membrane protein involved in several types of cancer together with a compound that could serve as a drug to treat those cancers. 

“So many things change in 3-D, it’s mind-blowing – when you look at the function of the cell, how they present their proteins, how they activate genes, how they interact with other cells,” said Jeanne Becker, Ph.D., a cell biologist at Nano3D Biosciences in Houston and principal investigator for a study called Cellular Biotechnology Operations Support Systems: Evaluation of Ovarian Tumor Cell Growth and Gene Expression, also known as the CBOSS-1-Ovarian study. “The variable that you are most looking at here is gravity, and you can’t really take away gravity on Earth. You have to go where gravity is reduced.“ 

Crunching Big Data Using Space Knowledge

Our Jet Propulsion Laboratory often deals with measurements from a variety of sensors – say, cameras and mass spectrometers that are on our spacecraft. Both can be used to study a star, planet or similar target object. But it takes special software to recognize that readings from very different instruments relate to one another.

There’s a similar problem in cancer research, where readings from different biomedical tests or instruments require correlation with one another. For that to happen, data have to be standardized, and algorithms must be “taught” to know what they’re looking for.

Because space exploration and cancer research share a similar challenge in that they both must analyze large datasets to find meaning, JPL and the National Cancer Institute renewed their research partnership to continue developing methods in data science that originated in space exploration and are now supporting new cancer discoveries.

JPL’s methods are leading to the development of a single, searchable network of cancer data that researcher can work into techniques for the early diagnosis of cancer or cancer risk. In the time they’ve worked together, the two organizations’ efforts have led to the discovery of six new Food and Drug Administration-approved cancer biomarkers. These agency-approved biomarkers have been used in more than 1 million patient diagnostic tests worldwide.

(Image caption: Brandeis University professor Ricardo Godoy conducts the experiment in a village in the Bolivian rainforest. The participants were asked to rate the pleasantness of various sounds, and Godoy recorded their response. Credit: Alan Schultz)

Why we like the music we do

In Western styles of music, from classical to pop, some combinations of notes are generally considered more pleasant than others. To most of our ears, a chord of C and G, for example, sounds much more agreeable than the grating combination of C and F# (which has historically been known as the “devil in music”).

For decades, neuroscientists have pondered whether this preference is somehow hardwired into our brains. A new study from MIT and Brandeis University suggests that the answer is no.

In a study of more than 100 people belonging to a remote Amazonian tribe with little or no exposure to Western music, the researchers found that dissonant chords such as the combination of C and F# were rated just as likeable as “consonant” chords, which feature simple integer ratios between the acoustical frequencies of the two notes.

“This study suggests that preferences for consonance over dissonance depend on exposure to Western musical culture, and that the preference is not innate,” says Josh McDermott, the Frederick A. and Carole J. Middleton Assistant Professor of Neuroscience in the Department of Brain and Cognitive Sciences at MIT.

McDermott and Ricardo Godoy, a professor at Brandeis University, led the study, which appeared in Nature on July 13. Alan Schultz, an assistant professor of medical anthropology at Baylor University, and Eduardo Undurraga, a senior research associate at Brandeis’ Heller School for Social Policy and Management, are also authors of the paper.

Consonance and dissonance

For centuries, some scientists have hypothesized that the brain is wired to respond favorably to consonant chords such as the fifth (so-called because one of the notes is five notes higher than the other). Musicians in societies dating at least as far back as the ancient Greeks noticed that in the fifth and other consonant chords, the ratio of frequencies of the two notes is usually based on integers — in the case of the fifth, a ratio of 3:2. The combination of C and G is often called “the perfect fifth.”

Others believe that these preferences are culturally determined, as a result of exposure to music featuring consonant chords. This debate has been difficult to resolve, in large part because nowadays there are very few people in the world who are not familiar with Western music and its consonant chords.

“It’s pretty hard to find people who don’t have a lot of exposure to Western pop music due to its diffusion around the world,” McDermott says. “Most people hear a lot of Western music, and Western music has a lot of consonant chords in it. It’s thus been hard to rule out the possibility that we like consonance because that’s what we’re used to, but also hard to provide a definitive test.”

In 2010, Godoy, an anthropologist who has been studying an Amazonian tribe known as the Tsimane for many years, asked McDermott to collaborate on a study of how the Tsimane respond to music. Most of the Tsimane, a farming and foraging society of about 12,000 people, have very limited exposure to Western music.

“They vary a lot in how close they live to towns and urban centers,” Godoy says. “Among the folks who live very far, several days away, they don’t have too much contact with Western music.”

The Tsimane’s own music features both singing and instrumental performance, but usually by only one person at a time.

Dramatic differences

The researchers did two sets of studies, one in 2011 and one in 2015. In each study, they asked participants to rate how much they liked dissonant and consonant chords. The researchers also performed experiments to make sure that the participants could tell the difference between dissonant and consonant sounds, and found that they could.

The team performed the same tests with a group of Spanish-speaking Bolivians who live in a small town near the Tsimane, and residents of the Bolivian capital, La Paz. They also tested groups of American musicians and nonmusicians.

“What we found is the preference for consonance over dissonance varies dramatically across those five groups,” McDermott says. “In the Tsimane it’s undetectable, and in the two groups in Bolivia, there’s a statistically significant but small preference. In the American groups it’s quite a bit larger, and it’s bigger in the musicians than in the nonmusicians.”

When asked to rate nonmusical sounds such as laughter and gasps, the Tsimane showed similar responses to the other groups. They also showed the same dislike for a musical quality known as acoustic roughness.

The findings suggest that it is likely culture, and not a biological factor, that determines the common preference for consonant musical chords, says Brian Moore, a professor of psychology at Cambridge University, who was not involved in the study.

“Overall, the results of this exciting and well-designed study clearly suggest that the preference for certain musical intervals of those familiar with Western music depends on exposure to that music and not on an innate preference for certain frequency ratios,” Moore says.