Latest Posts by fraxxed - Page 5

Jan 8 2018/ 1/100 days

Today was my first day back at school! I have lots of work to do already on my giant research project.It is also my first time using my bullet journal for school and I quite like it (although this weeks spread is messed up)

Study identifies new brain death pathway in Alzheimer’s disease

Alzheimer’s disease tragically ravages the brains, memories and, ultimately, personalities of its victims. Now affecting 5 million Americans, Alzheimer’s disease is the sixth-leading cause of death in the U.S., and a cure for Alzheimer’s remains elusive, as the exact biological events that trigger it are still unknown.

In a new study, Arizona State University-Banner Health neuroscientist Salvatore Oddo and his colleagues from Phoenix’s Translational Genomics Research Institute (TGen) — as well as the University of California, Irvine, and Mount Sinai in New York — have identified a new way for brain cells to become fated to die during Alzheimer’s disease.

The research team has found the first evidence that the activation of a biological pathway called necroptosis, which causes neuronal loss, is closely linked with Alzheimer’s severity, cognitive decline and extreme loss of tissue and brain weight that are all advanced hallmarks of the disease.

“We anticipate that our findings will spur a new area of Alzheimer’s disease research focused on further detailing the role of necroptosis and developing new therapeutic strategies aimed at blocking it,” said Oddo, the lead author of this study, and scientist at the ASU-Banner Neurodegenerative Disease Research Center at the Biodesign Institute and associate professor in the School of Life Sciences.

The findings appear in the advanced online edition of Nature Neuroscience.

Necroptosis, which causes cells to burst from the inside out and die, is triggered by a triad of proteins. It has been shown to play a central role in multiple sclerosis and Lou Gehrig’s disease (amyotrophic lateral sclerosis, or ALS), and now for the first time, also in Alzheimer’s disease.

“There is no doubt that the brains of people with Alzheimer’s disease have fewer neurons,” said Oddo. “The brain is much smaller and weighs less; it shrinks because neurons are dying. That has been known for 100 years, but until now, the mechanism wasn’t understood.”

Links with Alzheimer’s

Necroptosis was first identified as a result of inflammation, a common malady in Alzheimer’s.

Three critical proteins are involved in the initiation of necroptosis, known as RIPK1, RIPK3 and MLKL. The study describes a key event in the process of necroptosis when RIPK1 and RIPK3 form a filamentous structure known as the necrosome.

The formation of the necrosome appears to jump-start the process of necroptosis. It activates MLKL, which affects the cell’s mitochondria, eventually leading to cell death.

Winnie Liang, TGen assistant professor, director of TGen Scientific Operations and director of TGen’s Collaborative Sequencing Center, said MLKL executes necroptosis to ultimately cause cell death.

“In this study, we show for the first time that necroptosis is activated in Alzheimer’s disease, providing a plausible mechanism underlying neuronal loss in this disorder,” said Liang, who contributed to the study’s gene expression analyses.

To explore necroptosis, the research team utilized multiple cohorts of human samples obtained from the Brain and Body Donation Program at the Banner Sun Health Research Institute and Mount Sinai VA Medical Center Brain Bank.

First, they measured RIPK1, RIPK3 and MLKL in a specific region of the brain that is typically ravaged by cell loss during the advance of Alzheimer’s disease — the temporal gyrus. Results showed that during necroptosis, these markers were increased in the brains of people with Alzheimer’s disease.

Next, they identified the molecular cascade of necroptosis activation, with RIPK1 activating RIPK3 by binding with it. This protein complex then binds to and activates MLKL. Analysis of mRNA and protein revealed elevated levels of both RIPK1 and MLKL in the postmortem brain tissues of patients with Alzheimer’s when compared with normal postmortem brains.  

Furthermore, they also demonstrated that necroptosis activation correlated with the protein tau. Intriguingly, necroptosis did not appear to be linked with the other chief physiological characteristic of Alzheimer’s pathology, beta-amyloid plaque.

Engines of decline

To assess the relationship between necroptotic protein levels and cognitive health, the study revisited the scores of patients whose postmortem brain tissue was evaluated for necroptosis. Results showed a significant association between RIPK1, MLKL and diminished scores on the Mini-Mental State Examination (MMSE), a widely used test measuring cognitive health.

Given the established relationship between necroptosis and Alzheimer’s pathology, including cell loss and attendant cognitive deficit, the study sought to inhibit the process to study the dynamic effects on cell death and memory loss.

With such experiments not possible in people, the team demonstrated in a mouse model of the disease that lowering the activation of the necroptosis pathway reduces cell loss and improves performance in memory-related tasks, offering new hope for human therapeutics to halt or reverse the effects of Alzheimer’s.

The results reveal that the inhibition of necroptosis activation through the blockage of RIPK1 prevents cell loss in mice. Compellingly, mice with inhibited activation of necroptosis pathways performed significantly better in tests of spatial memory involving navigation through a water maze.

New understanding, new hope

The study opens a new window on Alzheimer’s research and offers hope for therapies targeting cell loss in the brain, an inevitable and devastating outcome of Alzheimer’s progression.

Oddo stresses that RIPK1, RIPK3 and MLKL are among many potential drug targets, and others will likely follow as the links between necroptosis and Alzheimer’s become clearer. While multiple causes of the disease are likely, understanding more clearly all targets that trigger disease will offer the best hope since neuronal loss has been found in people more than a decade before any symptoms of dementia.

“One may not agree as to which molecules trigger Alzheimer’s disease, ” said Oddo, “but everybody agrees that the end result is the neuronal loss. If you can prevent that you may have a beneficial effect.”

hello hello and happy new year !!!! i’m bia | @thegreenau and i decided to take 2018 by the reins and create a studyblr. 

here are a couple facts about me:

first of all i can’t type at all lmao i always have so many typos its terrible and i’m using autocorrect right now so i don’t scare everyone away

my name is bia and i use she/her pronouns

i’m sixteen years old and born and raised in california

i’m of indian descent and i am muslim

i’m in my junior year of high school, set to graduate in 2019

i play tennis and i swim

i love traveling, i love reading, i love one direction (yikes look at my main), and i love connecting with people on this website because we have interests in common

i used to love studying. learning and studying were some of my favorite things to do and ever since i hit high school i kinda started hating those things, which is terrible because i force myself to get good grades anyways. i want to love studying again, and hopefully having a studyblr will help !

i’m in four ap classes (ap chemistry, ap english language, ap calculus ab, and ap psychology) and i aim for straight a’s

i’m also taking spanish iii and choir

school is very important to me and like i mentioned before, i want to enjoy it as much as possible. i think i should stop dreading it considering that i spend all day in school and it consumes some of my time at home too.

anwyays i jsut turned autotcorrect off so yall can see hwo it looksw hen i type noramaly andi woudl like to formallfy apolgoize yiekes

some blogs i admire:

@emmastudies @gravity-studies @smartime @studytherin @moonshinestudies

@einstetic @alimastudies @focusign @elkstudies @areistotle @wlwstudies

@study-matters @revisoin @studyquill @studypetals @studyplants

anyways, this was my little intro post. i hope 2018 treats everyone well. i am so excited to be a part of this amazing studyblr community !!! 

xx bia

hello!

I’m Anna - I’ve recently restarted running my studyblr in the hopes of it helping me motivate myself and help me take an initiative in being more organized for the new year. Hopefully I’ll meet some new people in the community and we can be friends!

about me:                                                                                                                        - I love tomatoes                                                                                                     - I love running (short distance)                                                                                                  - I just recently started highschool                                                                                                  - Yellow is my fav color                                                                                                  - I speak Russian and English                                                                                                  - I can play the ukulele                                                                                                - I live for memes 

*  if we have anything in common, message me! we can bond ha *

my fav studyblrs 

@cloudedstudy - @studyblr - @studign - @emmastudies  - @acadmia - @physike - @wildliners - @intellectys - @studynine - @stu-pidest - @teacomets - @sadgirlstudying - @no-cake-where - @hannahstudies - @studythetics - @revisoin - @aou - @studyisms - @altairstudy - @minimalismstudies

pls reblog or like if you’re a studyblr, I’m always looking for new studyblr accounts to follow. 

hope you all had a great 2017 and have an even better 2018!

reblog if you post:

positive text post, doddles, reminders graphics

pro-recovery 💛

soft and warm/gentle suggestions

art stuff (your own art, paintings from famous, local, indie, orr not artists, etc)

journals (bullet), sketchpads, tips

studyblr, motivation, inspo

photography (your own shots mostly portraits or urban-based/forest-y with warm temperature)

funny or wholesome memes haha

fashion/room inspo/your cute ootds

harry potter or anime (specifically haikyu, boku no hero academia, or studio ghibli films, etc)

flowers and sunshine stuff (a lot of potted or hanging plants and flowers)

poems, prose that talk about equality, women empowerment, black lives matter, breaking stigma, etc

yellow/peach aesthetic snaps

cute animals that make your heart !!!! (mostly doggooooss!!!)

you post your own stuff (selfies are welcome, your own shots, etc)

other stuff that reminds you of sunshine

i recently hit a milestone and to serve as my thanks to you, this is a follow spree! i’ll be queueing a tad of stuff from whoever reblogs this! pls make sure you’re following me as well 🍒

ya know what I want to see more of in the study/bujo community

I want to see more dark photos.

I want to see more photos with diverse, colourful, and interesting backgrounds.

I want to see more notes written in ballpoint

I want to see more of the rushed bujo pages made because you didn’t have time to do it but didn’t want to have that week missing from your journal

I want to see more in-class notes, the notes you took before you re-wrote them to make them “post worthy”

I want to see more messy desks. The aftermatch of journaling and studying

I want to see more wooden desks, more desks that aren’t white, more desks covered in coffee rings and paint splats

I want to see more on the fly photos

And I’m not writing this because I want to support “small accounts” or “poor study accounts” I want to see it because I’m sick of every single post looking the same as the one I saw last. I’m tired of accounts with amazing content not getting the growth they deserve because their photos aren’t overexposed on white desks. I want to see it because it stands out, it’s different, and I like it.

So many accounts quit before they even get started because of the precedent that you have to have expensive stationery and stark white photos to grow and make an impact. Because they don’t feel they can live up to the expectations of the community. And that makes me really sad.

[1/100 days of productivity] // started my multivariable calculus course

listening to: night changes - one direction

New year, new bujo, I guess!

Here’s what my cover, new years’ resolutions (I’ll post about those more in detail in another post) and weekly layout (while on break) look like. I promise it’ll be a lot nicer when school starts :)

Thank you so much for tagging me @studyingdayandnight

Things that make me happy are:

1. Listening to music

2. Rain in general

3. Learning about things that I find interesting

4. Working lights or management on a show

5. Drawing

Thank you all so much!!!!!

I'm tagging @studyign @studywithinspo @emmastudies @mattystudies @tbhstudying

Pass the happy! 💛 When you get this, reply with 5 things that make you happy and send this to the last 10 people in your notifications! 😊

Thank you!! So 5 things that make me happy…1.Reading 2Listening to music3.Going out with Family4.Talking/chatting with (online)/ rl friends5.(ridiculous but does make me happy) watching YOI or reading about it (Victuuri) very sweet can’t help itOk so for tagging here it is: @bujo-ie @lightbeanvibes @i-actually-study-a-lot @studyblr @interiorsthetic @elkstudies @nehrdist @notesworthtea @way-to-study @studydiaryofamedstudent

Finally ready for school tomorrow! I'm going to be starting the 100 days of productivity thing. Does anyone have any advice?

rb this n put ur schools mascot in the tags !

I feel like a lot of people don’t want to ask questions they have about gender/sexuality to LGBT people because they don’t want to offend them because we talk about cishet people asking stupid or intrusive questions a lot

But actually when you’re questioning it’s really helpful to be able to ask some ‘stupid’ questions although you’re too afraid to

So can y'all LGBTQIA+ people reblog this if you’re totally fine with people asking questions about your gender/sexuality, as long as they do so respectfully

STUDYBLR COMMUNITY

please like or reblog this if you’re a studyblr because I desperately want to follow more blogs, so I want to check out a bunch of blogs!! I’m especially looking for English lit/language and Italian language oriented blogs because I’m an English major and I’m planning on continuing my Italian studies soon. But I love quality content so even if you’re not English/Italian blog, I’ll still follow you!!

REBLOG IF YOU'RE A STUDYBLR.

I wanna see how many of us are there cx

Please support this project.

[02.01.2018] day 87 –

my brain, currently: chemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistrychemistry

also, I received an offer from the university of amsterdam today and I’m so happy!

Thanks for making this awesome activity @yuu-chii I crossed out lots more than I thought I would and I had such a hard time deciding if I prefer tea or coffee. I'm a sophomore (10th) in America and I'm very active in theatre and music at my school. I'm also a huge nerd who loves math and science. Thanks for this fun bingo game :)

@ everyone who went through a period of having no friends, who ate alone, who had a point in their life where they were too embarrassed to tell their parents they had no one to play with after school: I love you. I know it hurts and I know it’s hard but it’s not your fault. Things will grow and change. You will find people who you click with and they will love you too. You deserve positive friendship relationships just like anyone else. And if you’re still going through this phase, you’re strong, and things will change for you too. You are not alone, there are people experiencing the same thing you are, find them, you deserve positivity and companionship. Keep your head up.

STUDYBLR BINGO!

To celebrate how amazing and supportive my followers have been for sticking with me for more than a month now and to commemorate reaching 400+ followers, I created this game to get to know you all better. RULES - reblog this if you’re joining. - download the photo and cross out anything that applies to you  - re-upload with a short description of yourself and tag me! I’ll be creating a mood board for you based on this and what you post.

Tagging my beloved mutual studyblrs to join bc I want to get to know you better!! Also, thank you so much for being with me on my studyblr journey. It means a whole lot to me to be noticed by such amazing and inspiring people. Please keep doing what you do. @studyingwug // @nocturne-studies // @piiess // @ittybittystudyblr // @sweeterthanstudying // @lindzpng // @aistudy16 // @tealovingstudies // @solving-equations // @jackistudies // @rivkahstudies // @study-matters // @onthestudyingspot // @cupoftea-studies // @merida-studies // @vivianastudies // @flo-studies // @ludostudies // @elstudyblr // @saltysky // @materscience // @architstudy // @rui-writes // @greygubler

Welcome Shruti! Glad to see another high school studyblr If you need advice or just want to talk please message me :)

introduction

hi everyone! my name is shruti and i’ve been meaning to make a studyblr for a little while now. I love looking at notes and finding creative ways to take mine. 

about me:

I’m sixteen

I live in America

I am a junior (grade 11) in high school

I want to major in biomedical sciences

I love music, especially Ed Sheeran

I am obsessed with YouTube 

I play the piano (badly)

I love traveling and learning new languages

I play waterpolo

I’m a mix between a Hufflepuff and a Ravenclaw 

current courses: 

AP Statistics

AP US History

English

AP Biology

Honors Spanish

AP Seminar

Multivariable Calculus

goals: 

Complete 100 days of Productivity

Get all A’s in my classes

Make new friends

Find a balance between studying and sleep

favorite studyblrs in no particular order

@emmastudies //  @fuckstudy //  @tbhstudying // @studyign // @studymonday // @fvckstvdy // @studyingdayandnight // @stvdybuddies // @studyblrmasterposts // @studytune // @smallstudyblring // @nerdastically // @rad-study // @studyquill

I’m super excited to join this community! thank you for reading and i’m excited to start posting original content soon! I’m also looking for fellow studyblrs to follow so like/reblog/send me an ask and I’ll follow! 

has this been done yet

As a student, it’s so important to love yourself because if you don’t it’s going to translate into sacrificing your wellbeing for grades and not being able to cope with failure because you let it define you. So I’m telling you now, grades do not determine your worth as a person. If you can convince yourself that you are worthy and valuable as an individual, you’ll find your journey so much less stressful.

1 / 4 / 18

 I’ve been working on my bullet journal and I’ve finished my monthly layout page for January! Please ignore the faded writing in the middle, that’s writing on the other side of the page. 

 I’m super happy with how this came out! I found a spread on Pinterest that I really liked and used some aspects of it for mine. Also on the far right is a little doodle I did of my best friend, who joked I should put her in my bullet journal. I love how it looks and will have a new one of her each month!

Relax, you will be okay.

Inspired by @lightheartedsuggestion 

3 january, 2018 re-reading hamlet for literature

featuring my messy nail polish

Reblog if it’s okay to befriend you, ask questions, ask for advice, rant, vent, let something off your chest, or just have a nice chat.

04-01-17 (Post 11)

Reviewing some Environmental Science I did yesterday because I fell asleep without reviewing anything (whoops) Going out later today to find some new frames (glasses) Don’t know how productive I’m going to be today as I’m some what behind schedule already. How’s your day going? ~

*click for better quality Tumblr is so annoying*

Going for GOLD

On Jan. 25, we’re going for GOLD!

We’re launching an instrument called Global-scale Observations of the Limb and Disk, GOLD for short. It’s a new mission that will study a complicated — and not yet fully understood — region of near-Earth space, called the ionosphere.

Space is not completely empty: It’s teeming with fast-moving energized particles and electric and magnetic fields that guide their motion. At the boundary between Earth’s atmosphere and space, these particles and fields — the ionosphere — co-exist with the upper reaches of the neutral atmosphere.

That makes this a complicated place. Big events in the lower atmosphere, like hurricanes or tsunamis, can create waves that travel all the way up to that interface to space, changing the wind patterns and causing disruptions.

It’s also affected by space weather. The Sun is a dynamic star, and it releases spurts of energized particles and blasts of solar material carrying electric and magnetic fields that travel out through the solar system. Depending on their direction, these bursts have the potential to disrupt space near Earth.

This combination of factors makes it hard to predict changes in the ionosphere — and that can have a big impact. Communications signals, like radio waves and signals that make our GPS systems work, travel through this region, and sudden changes can distort them or even cut them off completely.

Low-Earth orbiting satellites — including the International Space Station — also fly through the ionosphere, so understanding how it fluctuates is important for protecting these satellites and astronauts.  

GOLD is a spectrograph, an instrument that breaks light down into its component wavelengths, measuring their intensities. Breaking light up like this helps scientists see the behavior of individual chemical elements — for instance, separating the amount of oxygen versus nitrogen. GOLD sees in far ultraviolet light, a type of light that’s invisible to our eyes.

GOLD is a hosted payload. The instrument is hitching a ride aboard SES-14, a commercial communications satellite built by Airbus for SES Government Solutions, which owns and operates the satellite.

Also launching this year is the Ionospheric Connection Explorer, or ICON, which will also study the ionosphere and neutral upper atmosphere. But while GOLD will fly in geostationary orbit some 22,000 miles above the Western Hemisphere, ICON will fly just 350 miles above Earth, able to gather close up images of this region.

Together, these missions give us an unprecedented look at the ionosphere and upper atmosphere, helping us understand the very nature of how our planet interacts with space.

To learn more about this region of space and the GOLD mission, visit: nasa.gov/gold.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.  

bullet journaling is what’s keeping me sane. studygram

Thank you for letting us know that our work is still valued. Sometimes it is hard to remember that with all of the beautiful notes. Here’s to all the messy and unorganized studyblrs!

Studyblrs with messy notes full of re-writes and crossings out.

Studyblrs with pens that only work half the time and cheap stationary and basic notebooks from Tescos. 

Studyblrs that don’t or can’t take aesthetic af photos with amazing lighting. 

Studyblrs that struggle to keep up with their work and aren’t super organised. 

Studyblrs that don’t keep or own beautifully hand-drawn bujo spreads full of art and quotes. 

Studyblrs that don’t have Tumblr friends/family, who don’t recieve 20,000 asks/messages everyday, who don’t actually talk to anyone.

Your work is valuable, your studies are valuable, you are valuable, and I love you being a part of the community.   

IF YOU ARE A STUDYBLR

Please reblog this post so I can check your blog! I just got out of a hiatus and my dash is quite slow ♡