Emotional Walls Your Character Has Built (And What Might Finally Break Them)

the most horrifying part of this is that it's only going to get worse from here. this is the most stable climate this planet is going to have for the rest of our lives

Recipe Sandwiches with Vegetables 💖

Recipe Information:

BG

1-4-8 serve

Recipe Category: Appetizer, Lunch, Dinner, Vegetarian

Can cook without cooking skills

Healthy lifestyle

Ingredients are optional. One version:

Other recipes can be downloaded by tag Recipe Download

The recipe contains a custom cooking mesh- Sim slices bread, spinach and various vegetables

🤍Public Released on September 24th 2022

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🌸 comfy loungewear set // thank you for 2k!

hello! first of all, thank you for following my simblr and making this milestone happen!

as i’ve been creating more content over time, i decided to establish a dedicated patreon page for my cc. i don’t have any plans in terms of tiers at the moment - but stay tuned for updates regarding that later (if there are any lol)!

back to the loungewear set! i wanted to create more comfy outfits, plus i was also inspired by some cute color combos which i saw online :)

🌸 download + info under the cut!

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hare hare hare hare hare hare HAWK

(available as an 8x8 print from my store)

Funny things that I think probably happen with cyberware more often than Pondsmith and CDPR would write in the text but I just think they're neat if only from a wordbuilding perspective:

Hair getting caught in your deep dive port when you try to plug the link in.

Your sleeves getting stuck in the seams of your arm cyberware when the mechanisms retract back in.

Mantis blades accidentally shredding your long sleeves when you flex them.

A ripperdoc not having your exact shade of skintone on your new limb, and telling you to wait to get it replaced while it's on backorder.

Blue Screen of Death on netrunner 'ware.

Needing to register the new fingerprints on your hand if you get it replaced with a cybernetic, and the complications of having two hands that might not match up printwise.

People 'tattooing' the chromed parts of their body via laser engraving.

Metal plating getting so hot during the summer that you accidentally burn yourself trying to scratch your nose.

Forgetting to deslot shards and accidentally carrying them around in your head for a week.

Needing to clean the gunk out of your mantis blades or projectile launcher at home, so you flex it open and scrub at it with a bunch of paper towels or a bristle brush for an hour.

Rust and tarnish cleaner being a staple in home cyberware maintenance.

Actually buying projectile launcher rounds.

Someone starting a Mythbusters/Jackass style TV show about cyberware ("Hey gang! Today we're asking 'Is it possible to punch through a 3-foot cinderblock wall using only seven-gen Gorilla Fists?'")

Just generally playing with your personal link. Strumming it. Spinning it. Thwacking people with it. Built in fidget toy.

Fish nature and flowers

Also

Oh fishmas tree oh fishmas tree (the 7th one..)

Thank you so much for this this, your spotted fish lead to me learning something new about emoji kitchen

Pharmacology Unveiled: How Medications Work on a Molecular Level"

Explore the science of pharmacology and delve into the mechanisms of action of commonly prescribed medications, shedding light on how they interact with the body's systems.

In the multifaceted domain of pharmacology, an intricate symphony of molecular interactions orchestrates the therapeutic effects of medications. A profound comprehension of the molecular underpinnings of pharmacological actions is indispensable for healthcare professionals, pharmaceutical scientists, and researchers. In this discourse, we embark on a comprehensive exploration of pharmacodynamics, elucidating the profound intricacies of how medications function at the molecular level.

Pharmacodynamics: A Multilayered Discipline

Pharmacodynamics constitutes the extensive scrutiny of the manner in which drugs interlace with specific molecular targets, often referred to as receptors or enzymes, within the human organism. Medications are meticulously designed to effectuate alterations in biochemical pathways, receptor kinetics, or enzymatic processes, aiming to modulate physiological phenomena to alleviate symptoms or remediate pathological states.

Receptor-Mediated Pharmacological Actions

A pivotal facet of pharmacodynamics lies in the receptor-mediated actions of medications. Receptors are intricate protein entities, frequently situated on the extracellular or intracellular domains of cells, that play a pivotal role in cellular communication and homeostasis. When a medication interfaces with a receptor, it initiates a cascade of molecular events, which, contingent upon the context, may potentiate or impede the cellular response.

Agonists and Antagonists: Puppets of Molecular Dance

In the intricate theater of pharmacodynamics, medications assume roles as either agonists or antagonists. Agonists aptly mimic the endogenous ligands or signaling molecules, seamlessly integrating into the receptor's binding pocket. This engagement sets forth a conformational alteration in the receptor, instigating cellular events replicating or augmenting the physiological response. Conversely, antagonists function as molecular antagonists, obstructing the receptor and forestalling the binding of endogenous signaling molecules. Consequently, the physiological response is negated or attenuated.

Enzymatic Interference: Orchestrating Biochemical Concertos

Certain medications orchestrate their therapeutic influence through the intricate domain of enzyme inhibition. Enzymes are the catalytic workhorses governing biochemical transformations in biological systems. Medications that selectively inhibit or modulate these enzymes effectively regulate the pace or character of these metabolic reactions, rendering them invaluable in conditions characterized by aberrant enzyme function.

Ion Channel Choreography: Modulating Electrophysiological Ballets

A notable mechanism of pharmacological action entails the modulation of ion channels. These proteinaceous conduits, reposing within cellular membranes, govern the flux of ions across these barriers. Medications designed to engage with ion channels effectively influence the electrochemical signaling within cells. The modulation of ion channels is instrumental in conditions such as arrhythmias, epilepsy, and neuropathic pain.

Pharmacogenetics: Personalizing Medication Regimens

The burgeoning realm of pharmacogenetics delves into the impact of an individual's genetic repertoire on their medication response. Genetic polymorphisms can significantly influence drug metabolism, receptor sensitivities, and pharmacological efficacy. Tailoring medication regimens to align with an individual's genetic makeup represents a burgeoning paradigm in personalized medicine.

Pharmacology unfolds as an intricate tapestry of molecular engagements and multifarious mechanisms. Medications, hewn with precision, are intended to engage with specific molecular entities, be it receptors, enzymes, or ion channels, aiming to modulate intricate biochemical processes to achieve therapeutic ends.

References

Rang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2015). Rang & Dale's Pharmacology. Elsevier.

Katzung, B. G., & Trevor, A. J. (2021). Basic & Clinical Pharmacology. McGraw-Hill Education

Brunton, L. L., Knollmann, B. C., & Hilal-Dandan, R. (2020). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. McGraw-Hill Education.

GM tip: when describing food, it is tempting to go full George RR Martin and make the food sound as good as possible. However, consider the alternative: there is nothing more evocative about a fictional place, culture, or character than the specific way their food kinda sucks.

watch what happens when I find you.