Good Things Are Coming Towards You. ☀️

Great list of artists.

THC found to remove plaque-forming Alzheimer’s proteins, reduce inflammation, and protect nerve cells

Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.

While these exploratory studies were conducted in neurons grown in the laboratory, they may offer insight into the role of inflammation in Alzheimer’s disease and could provide clues to developing novel therapeutics for the disorder.

“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” says Salk Professor David Schubert, the senior author of the paper.

READ MORE ON SALK INSTITUTE FOR BIOLOGICAL STUDIES

Ref: Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. NPJ Aging and Mechanisms of Disease (23 June 2016) | DOI: 10.1038/npjamd.2016.12 | PDF (Open Access)

ABSTRACT

The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood. We use a proteotoxicity model based upon the inducible expression of Aβ in a human central nervous system nerve cell line to characterize a distinct form of nerve cell death caused by intracellular Aβ. It is shown that intracellular Aβ initiates a toxic inflammatory response leading to the cell’s demise. Aβ induces the expression of multiple proinflammatory genes and an increase in both arachidonic acid and eicosanoids, including prostaglandins that are neuroprotective and leukotrienes that potentiate death. Cannabinoids such as tetrahydrocannabinol stimulate the removal of intraneuronal Aβ, block the inflammatory response, and are protective. Altogether these data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accumulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors.

Folorunsho Alakija… "The Richest Black Woman in the World"… It is popular belief that Oprah Winfrey is the Richest Black Woman in the world and according to Forbes she is, but in all actuality a born and raised Nigerian Woman from Lagos State named Folorunsho Alakija is close to $600 million richer than Oprah’s estimated net worth of $2.7 Billion according to new reports from Africa and America… Alakija is currently Worth about $3.3 billion but she started her career working as a secretary at the International Merchant Bank of Nigeria. She then traveled to England to study fashion design. On her return to Nigeria, she founded Supreme Stitches, which produced clothing for upscale clientele. Then, in 1993, without any prior experience in the oil business, she was awarded an oil prospecting license, allowing her company to explore for oil in one of Nigeria’s most prolific oil blocks. Alakija then became the founder and owner of Nigerian oil company Famfa Oil. She is a mother of 4 sons and built her Fortune from Oil and fashion and currently lives in Nigeria with her husband of 35 years. Alakija also heads a few philanthropic efforts to help people in need in her country of Nigeria and her Continent of Africa… @Champion_Us

Tales from the crypt

Horror | aminoapps.com

Tales from the crypt | Horror Amino

Tales from the crypt is a very influential horror series for me and really introduced me to the horr

Watch Vincent, Tim Burton’s Animated Tribute to Vincent Price & Edgar Allan Poe (1982)

Such a f*#king shame....another poor black brother!!😔😔

I’m torn about the photo choice. But those monsters should see what they’ve done. #Hate it!

Stone Execution names that took place in London.