Mercy Seems Like A Long Shot Here, So My Prayer For Inauguration Day 2025: May They Be Incompetent. May

I’m seeing a bunch of posts that make me think most USAmericans don’t know about The No Surprises Act.

It was passed in 2021 (thank you Biden) and essentially states that if you don’t have insurance or your insurance doesn’t cover a service you need (or want) you are entitled to a Good Faith Estimate of the cost of care. (If your insurance does cover the service, you should be able to estimate the cost of care based on your deductible and co-pay.)

As a healthcare provider who does not accept any insurance, I am very careful to not violate The No Surprises Act. Why? Because for every penny more than $400 that the Good Faith Estimate was “off” (or if it wasn’t provided), you are entitled to a refund for that amount.

Y’all. Ask for a Good Faith Estimate. Get it in writing. Compare it to what you are paying. If you are not provided an estimate or if it’s wrong by more than $400, demand a refund.

Given the misinformation that's been going around and will be going around, thought this might be helpful to some people

For a lot of reasons, I'm very good at this/at searching, to the point where I have worked as a professional fact-checker for two different publishers. So, here goes:

My Article Fact-Checking Protocol

Thorough Version

Read the full article. Keep an eye out for emotionally loaded words, and all-or-nothing language

Keep an eye out or anything that sounds too good to be true, and in contrast, anything that sounds so awful it must be true

Run the website/source through the amazing Media Bias/Fact Check. They'll tell you about a publication's bias and history of accuracy

Go to the website's home page and read through the headlines. Look at what topics they cover/prioritize, sensationalist headlines, and whether they're framing anything in a way that feels odd/off to you

Do a search related to the topic. This can be keywords, a question, or even just copy-paste the article title (Recommended: use DuckDuckGo so the results don't change based on what Google thinks they can sell you)

If multiple highly credible sources that say the same thing pop up, and there's no major societal biases that might affect the coverage of the topic in those sources (e.g. anything related to the Israel-Palestine conflict/Palestinian genocide, no matter which side), then I'm done!

If there are major societal biases, or I can't get a consensus of sufficiently credible sources, then I do some combination of:

(1) search the topic again + the words "controversy" and/or "fake"

(2) search the opposite of the topic, or do some sort of other filtered search

(3) look up a sufficiently credible news outlet with the opposite point of view of my source, and see what they have to say

(4) if it's a big enough topic, start by looking up 2 of the top national papers and 1 major paper for your region (I usually do the ones in the US, because that's where I am In the US: the LA Times, the Washington Post, and the NY Times)

Adjust "news" to "relevant type of source, e.g. tech, environmental" as relevant for all of the above options

If no red flags come up, and it's a topic I understand enough to smell huge bullshit,

Then I'm usually done!

If there are red flags, or I actually need a certain amount of detail/understanding, then it gets more complicated, but that would be a whole other thing to break down and such

or

tl;dr

Quick Version

Read the full article. Keep an eye out for emotionally loaded words, and all-or-nothing language

Keep an eye out or anything that sounds too good to be true, and in contrast, anything that sounds so awful it must be true.

If I don't know the website:

Run the website/source through the amazing Media Bias/Fact Check. They'll tell you about a publication's bias and history of accuracy

If I trust the source, but something else pinged my radar:

Do a quick web search to verify anything that sounds suspicious or too good/bad to be true (Recommended: use DuckDuckGo)

The Blues Brothers (1980)

Not where you grew up. Not where you’ll be living soon. Where you’re living right now.

Good News Network

Researchers Discover New Mechanism for Rapid Liver Regeneration to Restore Damaged Livers

Researchers discovered a mechanism after acute liver damage occurs—and it could lead to treatments for those with severe liver problems.

"Researchers at the National Cancer Research Centre in Spain (CNIO) have discovered a mechanism that is triggered just minutes after acute liver damage occurs—and it could lead to treatments for those with severe liver problems.

The avenues for future treatments of liver damage include a diet enriched with the amino acid glutamate.

“Glutamate supplementation can promote liver regeneration and benefit patients in recovery following hepatectomy or awaiting a transplant,” wrote the authors in a paper published in ‘Nature’.

The liver is a vital organ, crucial to digestion, metabolism, and the elimination of toxins. It has a unique ability to regenerate, which allows it to replace liver cells damaged by the very toxins that these cells eliminate.

However, the liver stops regenerating in cases of diseases that involve chronic liver damage–such as cirrhosis—and such diseases are becoming increasingly prevalent, associated with poor dietary habits or alcohol consumption. So activating liver regeneration is key to treating the disease.

Learning to activate liver regeneration is therefore a priority today, to benefit patients with liver damage and also those who’ve had part of their liver cut out to remove a tumor.

The research has discovered in animal models this previously unknown mechanism of liver regeneration. It is a process that is triggered very quickly, just a few minutes after acute liver damage occurs, with the amino acid glutamate playing a key role.

“Our results describe a fundamental and universal mechanism that allows the liver to regenerate after acute damage,” explained Nabil Djouder, head of the CNIO Growth Factors, Nutrients and Cancer Group and senior author of the study.

A “complex and ingenious” perspective on liver regeneration

Liver regeneration was known to occur through the proliferation of liver cells, known as hepatocytes. However, the molecular mechanisms involved were not fully understood. This current discovery is very novel, as it describes communication between two different organs, the liver and bone marrow, involving the immune system, according to a CINO news release.

The results show that liver and bone marrow are interconnected by glutamate. After acute liver damage, liver cells, called hepatocytes, produce glutamate and send it into the bloodstream; through the blood, glutamate reaches the bone marrow, inside the bones, where it activates monocytes, a type of immune system cell. Monocytes then travel to the liver and along the way become macrophages – also immune cells. The presence of glutamate reprograms the metabolism of macrophages, and these consequently begin to secrete a growth factor that leads to an increase in hepatocyte production.

In other words, a rapid chain of events allows glutamate to trigger liver regeneration in just minutes, through changes in the macrophage metabolism. It is, says Djouder, “a new, complex and ingenious perspective on how the liver stimulates its own regeneration.”

The research also clarifies a previously unanswered question: how the various areas of the liver are coordinated during regeneration. In the liver, there are different types of hepatocytes, organized in different areas; the hepatocytes in each area perform specific metabolic functions. The study reveals that hepatocytes producing a protein known as glutamine synthetase, which regulates glutamate levels, play a key role in regeneration.

According to the CNIO group, when glutamine synthetase is inhibited, there is more glutamate in circulation, which accelerates liver regeneration. This is what happens when the liver suffers acute damage: glutamine synthase activity decreases, blood glutamate increases, and from there, the connection with the bone marrow is established, reprogramming macrophages and stimulating hepatocyte proliferation.

Possible therapeutic applications

The experiments have been carried out in mice, but the results have been tested with bioinformatics tools, using databases of mouse and human hepatocytes.

According to Djouder, “dietary glutamate supplementation may simply be recommended in the future after liver extirpation, and also to reduce liver damage caused by cirrhosis.”

The first author of the paper, CNIO researcher María del Mar Rigual also wants future research to explore using glutamate supplements in humans who have undergone liver resection for tumor removal."

-via Good News Network, March 30, 2025