Ourvioletdeath - Inner Ramblings Of The Mind

the sketch of this was super old but I finished coloring it for WLF for 413 ohoh

it’s up as print!

Your MC knows they’re in a story, and makes full use of all the tropes to come out a hero every time. Trouble is, there’s a real hero emerging in the city, which presents the MC with a choice: remain a hero and watch the story crumble around them, or become a villain and save the world

The reason aliens have not invaded Earth is due to our television transmission. Since they have no concept of televised entertainment, they view everything seen as fact.

Hey friends, my book on fighting depression, How Hard It Really Is, is on sale for only 1.99. From a painstaking year and a half of research, interviews, and surveys, take a journey with me through managing mental illness and navigating the surprising truths and myths about depression.

Ebook sale: https://www.amazon.com/How-Hard-It-Really-Is-ebook/dp/B073TX15LB

The paperback is also only 8.99 here: https://www.amazon.com/How-Hard-It-Really-Is/dp/0692910360

For my quick video on depression: https://www.youtube.com/watch?v=xggg6xFObIE

In a horrible twist of fate, you and your worst enemy are soulmates. Tell the story of how you two reluctantly fall in love.

Your grandmother bequeaths a statue of an angel to you in her will. You find it creepy, but not having the heart to sell it, you store it in the basement. The next morning, to your horror, the basement door is wide open, and there is a note lying where you left the statue. Picking it up, you barely make out the scrawled words. “Find me before I find you.” 

The bassoon causing new brain disorder

Mutations have been found in the bassoon (BSN) gene, which is involved with the central nervous system, in patients with symptoms similar to, but different from, a rare brain disorder called progressive supranuclear palsy (PSP).

PSP, a form of Parkinson’s disease, is often difficult to diagnose because it can affect people in different ways. Serious problems often include difficulty with walking and balance in addition to a decline in cognitive abilities such as frontal lobe dysfunction.

A team of Japanese researchers investigated patients whose symptoms resembled not only PSP but also Alzheimer’s disease. Despite similarities in the symptoms, detailed pathological analyses showed no resemblance to either disease, which prompted the team to further research the new disease’s underlying mechanism.

They first analyzed the genomes of a Japanese family with several members displaying PSP-like symptoms. They identified a mutation in the BSN gene only in family members with symptoms. These individuals did not have mutations in the 52 other genes associated with PSP and other neurological disorders such as Alzheimer’s and Parkinson’s. This was the first time BSN gene is associated with a neurological disorder.

(Image caption: MRI analysis of a patient with PSP-like symptoms showed severe atrophy of the bilateral hippocampus, mesencephalic tegmentum, cerebellum, and brainstem. Credit: Yabe I. et al., Scientific Reports, January 16, 2018)

The researchers also detected three other mutations in the BSN gene in four out of 41 other patients displaying sporadic, or non-familial, PSP-like symptoms. None of the BSN mutations were detected in a random sample of 100 healthy individuals, underscoring the strong involvement of BSN mutations in the disease.

An autopsy done on one of the family members with the BSN mutation showed an accumulation of a protein called tau in the brain, which is not seen in a normal brain. The researchers believe that the BSN mutation is involved in the tau accumulation, which could cause the development of PSP-like symptoms. An experiment introducing a mutated rat BSN gene to cultured cells also suggested that the mutation causes the accumulation of tau. Communication between nerve fibres could also be affected, as BSN protein play a role in it.

(Image caption: Tau proteins accumulated in the brain of a patient with PSP-like symptoms. Credit: Yabe I. et al., Scientific Reports, January 16, 2018)

“This is a peculiar neurodegenerative disorder which involves mutations in the BSN gene and tau accumulation, but differs from any known disease, including dementia, Parkinson’s, and even PSP,” says Associate Professor Ichiro Yabe of Hokkaido University who led the study. “Patients with PSP-like symptoms and other neurodegenerative disorders should be analyzed for BSN mutations to fine-tune their diagnoses.”

I'm so infuriated by Alberta right now. Ram a pipeline through BC because whatever, who cares about first nations or salmon or climate change but then, like raging hypocrites, they decide to invest millions into green energy, green economics and infrastructure in their own province. Lord, sometimes. Don't get me wrong, I'm excited about what I've read so far because it's absolutely the right direction for Canada... but how bout not taking one step forward for every three steps backwards.

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