“My Domain Is Time,” Said The Genie. “Instead Of Three Wishes, You Get Three Decisions. Go Back

Consider A Pet Monkey

(Image caption: Two Aplysia sensory neurons with synaptic contacts on the same motor neuron in culture after isolation from the nervous system of Aplysia. The motor neuron has been injected with a fluorescent molecule that blocks the activity of a specific Protein Kinase M molecule. Credit: Schacher Lab/Columbia University Medical Center)

Select Memories Can Be Erased, Leaving Others Intact

Different types of memories stored in the same neuron of the marine snail Aplysia can be selectively erased, according to a new study by researchers at Columbia University Medical Center (CUMC) and McGill University and published in Current Biology.

The findings suggest that it may be possible to develop drugs to delete memories that trigger anxiety and post-traumatic stress disorder (PTSD) without affecting other important memories of past events.

During emotional or traumatic events, multiple memories can become encoded, including memories of any incidental information that is present when the event occurs. In the case of a traumatic experience, the incidental, or neutral, information can trigger anxiety attacks long after the event has occurred, say the researchers.

“The example I like to give is, if you are walking in a high-crime area and you take a shortcut through a dark alley and get mugged, and then you happen to see a mailbox nearby, you might get really nervous when you want to mail something later on,” says Samuel Schacher, PhD, a professor of neuroscience in the Department of Psychiatry at CUMC and co-author of the paper. In the example, fear of dark alleys is an associative memory that provides important information—e.g., fear of dark alleys—based on a previous experience. Fear of mailboxes, however, is an incidental, non-associative memory that is not directly related to the traumatic event.

“One focus of our current research is to develop strategies to eliminate problematic non-associative memories that may become stamped on the brain during a traumatic experience without harming associative memories, which can help people make informed decisions in the future—like not taking shortcuts through dark alleys in high-crime areas,” Dr. Schacher adds.

Brains create long-term memories, in part, by increasing the strength of connections between neurons and maintaining those connections over time. Previous research suggested that increases in synaptic strength in creating associative and non-associative memories share common properties. This suggests that selectively eliminating non-associative synaptic memories would be impossible, because for any one neuron, a single mechanism would be responsible for maintaining all forms of synaptic memories.

The new study tested that hypothesis by stimulating two sensory neurons connected to a single motor neuron of the marine snail Aplysia; one sensory neuron was stimulated to induce an associative memory and the other to induce a non-associative memory.

By measuring the strength of each connection, the researchers found that the increase in the strength of each connection produced by the different stimuli was maintained by a different form of a Protein Kinase M (PKM) molecule (PKM Apl III for associative synaptic memory and PKM Apl I for non-associative). They found that each memory could be erased – without affecting the other — by blocking one of the PKM molecules.

In addition, they found that specific synaptic memories may also be erased by blocking the function of distinct variants of other molecules that either help produce PKMs or protect them from breaking down.

The researchers say that their results could be useful in understanding human memory because vertebrates have similar versions of the Aplysia PKM proteins that participate in the formation of long-term memories. In addition, the PKM-protecting protein KIBRA is expressed in humans, and mutations of this gene produce intellectual disability.

“Memory erasure has the potential to alleviate PTSD and anxiety disorders by removing the non-associative memory that causes the maladaptive physiological response,” says Jiangyuan Hu, PhD, an associate research scientist in the Department of Psychiatry at CUMC and co-author of the paper. “By isolating the exact molecules that maintain non-associative memory, we may be able to develop drugs that can treat anxiety without affecting the patient’s normal memory of past events.”

“Our study is a ‘proof of principle’ that presents an opportunity for developing strategies and perhaps therapies to address anxiety,” said Dr. Schacher. “For example, because memories are still likely to change immediately after recollection, a therapist may help to ‘rewrite’ a non-associative memory by administering a drug that inhibits the maintenance of non-associative memory.”

Future studies in preclinical models are needed to better understand how PKMs are produced and localized at the synapse before researchers can determine which drugs may weaken non-associative memories.

You get a penny every time you help someone. You notice nobody else has ever gotten a penny when they helped others, so you asked. But the person you asked didn’t answer, they just responded “You’ll know when you’re 30…” You’re 30 now, and your parents threw you a surprise party. All the people you ever helped were there. Your mother goes up to you, “So. You wanted to know why you got the pennies, right?”

Listen my dudes Ancient Egypt existed for a really fuckass long time. Literally just Pharaonic civilization lasted 3,000 years. That’s not even including predynastic civilization and Roman rule. If you lump that in you’re looking at more like… 5,000 years. Like. If you want a comparison of how long that is: THE YEAR IS CURRENTLY 2018. TWO THOUSAND. TWO-THIRDS OF ANCIENT EGYPTIAN PHARAONIC CIVILIZATION HAVE HAPPENED SINCE THE ‘BIRTH OF JESUS CHRIST’ We comparatively just entered the Third Intermediate Period. The Greeks will not take over for another 700~ years. Cleopatra will not be born until the year 2931.

It’s a really long time guys.

“It’s chaos. Be kind.”

biologists: no macroorganism can survive the endless vacuum of space unprotected for an extended period of time

lichens:

some of the pencil sketch commissions I’ve been doing for patrons the past months!

((I will draw/mail you a custom sketch of whichever character or oc you prefer each month you pledge, if you’re interested you can join here (=

Your first name is spelled and pronounced the exact same way as an alien race’s word for death. You try to explain to the terrified aliens that you are not, in fact, the Grim Reaper.

God, this was such a beautiful movie

Castle in the Sky