Latest Posts by philosophical-amoeba - Page 9

Curves of constant width

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The width of a circle is constant: its diameter.

But the circle is not the only shape that holds this pristine title. For instance let’s look at the Reuleaux triangle

Reuleaux triangle

A Reuleaux triangle is a shape formed from the intersection of three circular disks, each having its center on the boundary of the other two.

The Reuleaux triangle is the first of a sequence of Reuleaux polygons, curves of constant width formed from regular polygons with an odd number of sides.

Some of these curves have been used as the shapes of coins

To drill square holes.

They are not entirely square, their edges are fillets i.e the edges are rounded and not sharp.

This animation offers a good insight as to why that is so.

And in china, apparently on bicycles.

The man Guan Baihua shows his self-made multi-angle-wheel bicycle on May 6, 2009 in Qingdao of Shandong Province, China. Guan Baihua spent 18 months to complete this strange bicycle.

Other shapes of constant width

There are other shapes of constant width beside the Reuleaux triangle ( that has been discussed in this post ), a whole bunch of them really. Do take a look at them. ( links below )

I will leave you guys with my favorite one.

More:

If this post fascinated you, i strongly suggest you check these out. They go in-depth with the mathematics that underlies these curves and talk about other cool stuff:

An animation of non-circular rollers

Shapes and Solids of Constant Width - Numberphile  

Shapes of constant width

Reuleaux Polygons,           

Edit:

For those who are wondering if these are something that one would stumble upon on a regular basis. You may not find perfect ones but similiar ones definitely.

I found mine on a really old BMI calculator thingy. ( not sure what you would call it )

Have fun exploring !

How viruses infect bacteria: a tale of a tail

To infect bacteria, most bacteriophages employ a ‘tail’ that stabs and pierces the bacterium’s membrane to allow the virus’s genetic material to pass through. The most sophisticated tails consist of a contractile sheath surrounding a tube akin to a stretched coil spring at the nanoscale. When the virus attaches to the bacterial surface, the sheath contracts and drives the tube through it. All this is controlled by a million-atom baseplate structure at the end of the tail. EPFL scientists have now shown, in atomic detail, how the baseplate coordinates the virus’s attachment to a bacterium with the contraction of the tail’s sheath. The breakthrough has made the cover of Nature, and has important implications for science and medicine.

Nicholas M. I. Taylor, Nikolai S. Prokhorov, Ricardo C. Guerrero-Ferreira, Mikhail M. Shneider, Christopher Browning, Kenneth N. Goldie, Henning Stahlberg, Petr G. Leiman. Structure of the T4 baseplate and its function in triggering sheath contraction. Nature, 2016; 533 (7603): 346 DOI: 10.1038/nature17971

Bacteriophages are viruses that infect bacteria. Using state-of-the-art tools, EPFL scientists have described a million-atom “tail” that bacteriophages use to breach bacterial surfaces. The breakthrough has major implications for science and medicine, as bacteriophages are widely used in research.

Mary Anning

Mary Anning was born on 21 May in 1799, one of the most famous fossil finders of her day. This large skull was collected by Anning and is part of the skull and lower jaw of an ichthyosaur (Ichthyosaurus platyodon).

Mary Anning’s family had earned a living for years by gathering fossils on the shore at Lyme Regis in Dorset to sell to collectors. Mary learned about the fossils from her parents, Richard and Mary (‘Molly’) Anning. Despite the lack of a formal education, Mary Anning became an expert on the fossils she found, and the most eminent geologists of the day often sought her advice. In the 1820s she became the first person in Britain to find complete specimens of an ichthyosaur, a plesiosaur and a pterodactyl.

The specimens that Anning collected can still be found in museums throughout Britain. The British Museum purchased this example shortly after Anning discovered it.

On loan from the Natural History Museum.

Aristotle’s Wheel Paradox. Can you figure out what the paradox is? (What doesn’t make sense?) More info at http://mathworld.wolfram.com/AristotlesWheelParadox.html

Pacific Lamprey (Entosphenus tridentatus) 

Lampreys in their mature stage are parasites, latching onto other fish with their suction cup like mouths. Keratinised teeth rasp away their host’s skin, as the lamprey releases anticoagulants to ensure a steady supply of blood. Many victims die of infections or blood loss. 

Dave Herasimtschuk and Jeremy Monroe 

The Icelandic Language still uses the letters Þ and Ð, which used to be in the English alphabet too but which fell into disuse and were eventually left out altogether. Their pronunciation is the sound made by the “th” in “this” and “that” respectively.

Incidentally, the Þ was not included in early English printing press types. As a substitute they used y, which looks somewhat similar. Thus was the popular misconception born that English people used to say “ye” as in “ye old shoppe.”

On this day, 6th May 1840, the first adhesive postage stamp in the world, the Penny Black, came into official use in Great Britain.

It depicted a portrait of Queen Victoria and stamps continued with her image until her death in 1901.  All British stamps still show the monarch somewhere on the design. They are the only postage stamps in the world that do not indicate a country of origin; the monarch’s image symbolises the United Kingdom.       

The Penny Black lasted less than a year. A red cancellation was hard to see on the black design and the red ink was easy to remove; both made it possible to re-use cancelled stamps. In February 1841, the Treasury switched to the Penny Red and began using black ink for cancellations instead, which was more effective and harder to remove.

The State Library of New South Wales holds significant postage stamp collections, which include a number of penny black stamps -

Sir William Dixson Stamp Collection

1840 One Penny black Queen Victoria Recess printed Watermark Small Crown Imperf ( 1 mint, 3 used, 1 forgery )    and 

DP/M014 Series 02: Sir William Dixson Stamp Collection : Great Britain and Commonwealth Countries issued to 1952 Great Britain 1840

1840 One Penny black Recess printed Watermark Small Crown Imperf ( 6 used ) DP/M010 :- Box with miscellaneous items mounted on pages, numbered DP/M011 to DP/M127

A nurse has heart attack and describes what she felt like when having one

I am an ER nurse and this is the best description of this event that I have ever heard. 

 FEMALE HEART ATTACKS 

 I was aware that female heart attacks are different, but this is description is so incredibly visceral that I feel like I have an entire new understanding of what it feels like to be living the symptoms on the inside. Women rarely have the same dramatic symptoms that men have… you know, the sudden stabbing pain in the chest, the cold sweat, grabbing the chest & dropping to the floor the we see in movies. Here is the story of one woman’s experience with a heart attack: 

 "I had a heart attack at about 10:30 PM with NO prior exertion, NO prior emotional trauma that one would suspect might have brought it on. I was sitting all snugly & warm on a cold evening, with my purring cat in my lap, reading an interesting story my friend had sent me, and actually thinking, ‘A-A-h, this is the life, all cozy and warm in my soft, cushy Lazy Boy with my feet propped up. A moment later, I felt that awful sensation of indigestion, when you’ve been in a hurry and grabbed a bite of sandwich and washed it down with a dash of water, and that hurried bite seems to feel like you’ve swallowed a golf ball going down the esophagus in slow motion and it is most uncomfortable. You realize you shouldn’t have gulped it down so fast and needed to chew it more thoroughly and this time drink a glass of water to hasten its progress down to the stomach. This was my initial sensation–the only trouble was that I hadn’t taken a bite of anything since about 5:00 p.m. 

After it seemed to subside, the next sensation was like little squeezing motions that seemed to be racing up my SPINE (hind-sight, it was probably my aorta spasms), gaining speed as they continued racing up and under my sternum (breast bone, where one presses rhythmically when administering CPR). This fascinating process continued on into my throat and branched out into both jaws. ‘AHA!! NOW I stopped puzzling about what was happening – we all have read and/or heard about pain in the jaws being one of the signals of an MI happening, haven’t we? I said aloud to myself and the cat, Dear God, I think I’m having a heart attack! I lowered the foot rest dumping the cat from my lap, started to take a step and fell on the floor instead. I thought to myself, If this is a heart attack, I shouldn’t be walking into the next room where the phone is or anywhere else… but, on the other hand, if I don’t, nobody will know that I need help, and if I wait any longer I may not be able to get up in a moment. 

I pulled myself up with the arms of the chair, walked slowly into the next room and dialed the Paramedics… I told her I thought I was having a heart attack due to the pressure building under the sternum and radiating into my jaws. I didn’t feel hysterical or afraid, just stating the facts. She said she was sending the Paramedics over immediately, asked if the front door was near to me, and if so, to un-bolt the door and then lie down on the floor where they could see me when they came in. I unlocked the door and then laid down on the floor as instructed and lost consciousness, as I don’t remember the medics coming in, their examination, lifting me onto a gurney or getting me into their ambulance, or hearing the call they made to St. Jude ER on the way, but I did briefly awaken when we arrived and saw that the radiologist was already there in his surgical blues and cap, helping the medics pull my stretcher out of the ambulance. He was bending over me asking questions (probably something like ‘Have you taken any medications?’) but I couldn’t make my mind interpret what he was saying, or form an answer, and nodded off again, not waking up until the Cardiologist and partner had already threaded the teeny angiogram balloon up my femoral artery into the aorta and into my heart where they installed 2 side by side stints to hold open my right coronary artery. 

I know it sounds like all my thinking and actions at home must have taken at least 20-30 minutes before calling the paramedics, but actually it took perhaps 4-5 minutes before the call, and both the fire station and St Jude are only minutes away from my home, and my Cardiologist was already to go to the OR in his scrubs and get going on restarting my heart (which had stopped somewhere between my arrival and the procedure) and installing the stents. Why have I written all of this to you with so much detail? Because I want all of you who are so important in my life to know what I learned first hand. 

1. Be aware that something very different is happening in your body, not the usual men’s symptoms but inexplicable things happening (until my sternum and jaws got into the act). It is said that many more women than men die of their first (and last) MI because they didn’t know they were having one and commonly mistake it as indigestion, take some Maalox or other anti-heartburn preparation and go to bed, hoping they’ll feel better in the morning when they wake up… which doesn’t happen. My female friends, your symptoms might not be exactly like mine, so I advise you to call the Paramedics if ANYTHING is unpleasantly happening that you’ve not felt before. It is better to have a ‘false alarm’ visitation than to risk your life guessing what it might be! 2. Note that I said ‘Call the Paramedics.’ And if you can take an aspirin. Ladies, TIME IS OF THE ESSENCE! Do NOT try to drive yourself to the ER - you are a hazard to others on the road. Do NOT have your panicked husband who will be speeding and looking anxiously at what’s happening with you instead of the road. Do NOT call your doctor – he doesn’t know where you live and if it’s at night you won’t reach him anyway, and if it’s daytime, his assistants (or answering service) will tell you to call the Paramedics. He doesn’t carry the equipment in his car that you need to be saved! The Paramedics do, principally OXYGEN that you need ASAP. Your Dr. will be notified later. 3. Don’t assume it couldn’t be a heart attack because you have a normal cholesterol count. Research has discovered that a cholesterol elevated reading is rarely the cause of an MI (unless it’s unbelievably high and/or accompanied by high blood pressure). MIs are usually caused by long-term stress and inflammation in the body, which dumps all sorts of deadly hormones into your system to sludge things up in there. Pain in the jaw can wake you from a sound sleep. Let’s be careful and be aware. The more we know the better chance we could survive to tell the tale.“

Reblog, repost, Facebook, tweet, pin, email, morse code, fucking carrier pigeon this to save a life! I wish I knew who the author was. I’m definitely not the OP, actually think it might be an old chain email or even letter from back in the day. The version I saw floating around Facebook ended with “my cardiologist says mail this to 10 friends, maybe you’ll save one!” And knew this was way too interesting not to pass on.

What’s Up for May 2016?

What’s Up for May? Two huge solar system highlights: Mercury transits the sun and Mars is closer to Earth than it has been in 11 years.

On May 9, wake up early on the west coast or step out for coffee on the east coast to see our smallest planet cross the face of the sun. The transit will also be visible from most of South America, western Africa and western Europe.

A transit occurs when one astronomical body appears to move across the face of another as seen from Earth or from a spacecraft. But be safe! You’ll need to view the sun and Mercury through a solar filter when looking through a telescope or when projecting the image of the solar disk onto a safe surface. Look a little south of the sun’s Equator. It will take about 7 ½ hours for the tiny planet’s disk to cross the sun completely. Since Mercury is so tiny it will appear as a very small round speck, whether it’s seen through a telescope or projected through a solar filter. The next Mercury transit will be Nov. 11, 2019.

Two other May highlights involve Mars. On May 22 Mars opposition occurs. That’s when Mars, Earth and the sun all line up, with Earth directly in the middle.

Eight days later on May 30, Mars and Earth are nearest to each other in their orbits around the sun. Mars is over half a million miles closer to Earth at closest approach than at opposition. But you won’t see much change in the diameter and brightness between these two dates. As Mars comes closer to Earth in its orbit, it appears larger and larger and brighter and brighter. 

During this time Mars rises after the sun sets. The best time to see Mars at its brightest is when it is highest in the sky, around midnight in May and a little earlier in June. 

Through a telescope you can make out some of the dark features on the planet, some of the lighter features and sometimes polar ice and dust storm-obscured areas showing very little detail.

After close approach, Earth sweeps past Mars quickly. So the planet appears large and bright for only a couple weeks. 

But don’t worry if you miss 2016’s close approach. 2018’s will be even better, as Mars’ close approach will be, well, even closer.

You can find out about our #JourneytoMars missions at mars.nasa.gov, and you can learn about all of our missions at http://www.nasa.gov.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com

#🐌 #snail #pet #smallfriend #hyperlapse #timelapse http://ift.tt/1OF6qKr

NCLEX Pharmacology Medical Suffixes

-amil = calcium channel blockers

-caine = local anesthetics

-dine = anti-ulcer agents (H2 histamine blockers)

-done = opioid analgesics

-ide = oral hypoglycemics

-lam = anti-anxiety agents

-oxacin = broad spectrum antibiotics

-micin = antibiotics

-mide = diuretics

-mycin = antibiotics

-nuim = neuromuscular blockers

-olol = beta blockers

-pam = anti-anxiety agents

-pine = calcium channel blockers

-pril = ace inhibitors

-sone = steroids

-statin =antihyperlipidemics

-vir = anti-virais

-zide = diuretics

On this day, 29th April 1770,  Captain James Cook  first landed at Botany Bay,  (Sydney, Australia).

James Cook, with Joseph Banks and Daniel Solander landed at Kurnell in the afternoon of April 29th 1770, in search of fresh water. In the next few days, excursions around the bay were undertaken and samples of native flora collected, which proved so plentiful that Cook named the area Botany Bay.

The State Library of New South Wales holds many items relating to this voyage of the Endeavour, including Joseph Banks Journal and a copy of James Cook’s Endeavour log.

Portrait of Captain James Cook / painted by Sir Nathaniel Dance. Engraved by Cosmo Armstrong. State Library of New South Wales.

A Journal of the proceedings of His Majesty’s Bark Endeavour on a voyage round the world, by Lieutenant James Cook, Commander, commencing the 25th of May 1768 - 23 Oct. 1770 - Entrance of Endeavour River and Botany Bay Maps

Entanglement Made Simple, a divulgative article of theoretical physicist and Nobel laureate Frank Wilczek, in Quanta Magazine.

Image by James O'Brien for Quanta Magazine

For you military history enthusiasts out there!

World War II in Southeast Asia as shown by this map, titled Japanese Centrifugal Offensive (offense?) and its clashes with other European forces occupying the region, December 1941 - April 1942.

In blue are notable major battles such as the Battles of Sunda Strait (February 28), Java Sea (February 27), Balikpapan (January 23 - 24), Lombok Straits (February 18 - 19). After the surprising Pearl Harbor attack the Japanese managed to curb the European defense over Southeast Asia, also in a surprising manner due to unpreparedness. 

[Larger view] - [more photos]

Timbuktu was a center of the manuscript trade, with traders bringing Islamic texts from all over the Muslim world. Despite occupations and invasions of all kinds since then, scholars managed to preserve and even restore hundreds of thousands of manuscripts dating from the 13th century.

But that changed when militant Islamists backed by al-Qaida arrived in 2012.

The Bad-Ass Librarians of Timbuktu tells the story of librarian Abdel Kader Haidara, who organized and oversaw a secret plot to smuggle hundreds of thousands of medieval manuscripts out of Timbuktu before they could be destroyed by Islamist rebels.  

Hear author Joshua Hammer tell the story here.

– Petra

A Cry for Help.

I seek the Word of @cranquis and the Word of @wayfaringmd on proper tick removal technique. Where I live we’re being warned that populations will be high this summer and that 50% of the ticks are testing positive for Lyme disease. Between the cat, the dog, and three kids I know I’m going to have to deal with them soon.

I’m hearing so many conflicting things, even from MDs. Burn them with a match? Pour olive oil on them? I thought we weren’t supposed to do that stuff? Should I buy that fancy tick remover thing? Or does each one require a trip to the office? Help me Crayfaring, you’re my only hope! 😩

Awesome things you can do (or learn) through TensorFlow. From the site:

A Neural Network Playground

Um, What Is a Neural Network?

It’s a technique for building a computer program that learns from data. It is based very loosely on how we think the human brain works. First, a collection of software “neurons” are created and connected together, allowing them to send messages to each other. Next, the network is asked to solve a problem, which it attempts to do over and over, each time strengthening the connections that lead to success and diminishing those that lead to failure. For a more detailed introduction to neural networks, Michael Nielsen’s Neural Networks and Deep Learning is a good place to start. For more a more technical overview, try Deep Learning by Ian Goodfellow, Yoshua Bengio, and Aaron Courville.

GitHub

h-t FlowingData

The Black Book of Carmarthen is the oldest surviving manuscript written entirely in the Welsh language. It was penned by a single scribe working at different periods around the year 1250.

Read on

I just completed the finishing touches on my new poster, a detailed map of the Mandelbrot Set in a vintage style. I’m calling it the Mandelmap.

The Mandelbrot Set is a fractal shape with infinite detail that you can zoom in on. I often explore the Mandelbrot Set to find trippy patterns to create gifs with, but when I started I felt like I was just poking around at random. So I wanted to create a printed guide for myself to find my way around… I soon realized this was going to be a lot of work, so I decided I might as well take it to the next level and make an awesome poster that would be not just for myself but for everyone else to enjoy too.

What you see here is the result of more than a year’s research, planning, and execution. It’s a 36x24 inch poster rendered fully at 300 dpi, and everything you see was created from scratch. I will be posting more updates and information as I get the test prints in, and I hope to have this poster available to buy within the next couple months!

www.mandelmap.com

Word of the Day: potlatch

n. An opulent ceremonial feast (among certain North American Indian peoples of the north-west coast) at which possessions are given away or destroyed to display wealth or enhance prestige

Image: “Klallam people at Port Townsend” by James Gilchrist Swan. Public Domain via Wikimedia Commons

The @unirdg-collections Squint

The University of Reading holds the archive of original artwork for the much-loved Ladybird children’s book. This painting on board was used to illustrate Exploring Space, a Ladybird ‘Achievements’ Book first published in 1964. The artwork was created by Brian Knight.

If you look closely at the painting, you can see the faint trace of Knight’s initial design for the lunar landing module - just visible under the later amendment.

Published before the first Moon landing in 1969, the fantasy spacecraft was sleek and utopian. It typifies the extent to which The Space Race captured our mid-century imaginations and permeated visual culture. The later correction, based on the Eagle Lunar Module, was printed in subsequent revisions to the book. It was an acknowledgment of a successful mission and testament to Ladybird’s emphasis on accuracy for its young readers.

All artwork is © Ladybird Books Ltd.

(Image caption: If this picture makes you feel uncomfortable, you feel empathic pain. This sensation activates the same brain regions as real pain. © Kai Weinsziehr for MPG)

The anatomy of pain

Grimacing, we flinch when we see someone accidentally hit their thumb with a hammer. But is it really pain we feel? Researchers at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig and other institutions have now proposed a new theory that describes pain as a multi-layered gradual event which consists of specific pain components, such as a burning sensation in the hand, and more general components, such as negative emotions. A comparison of the brain activation patterns during both experiences could clarify which components the empathic response shares with real pain. 

Imagine you’re driving a nail into a wall with a hammer and accidentally bang your finger. You would probably injure finger tissue, feel physical distress, focus all your attention on your injured finger and take care not to repeat the misfortune. All this describes physical and psychological manifestations of “pain” – specifically, so-called nociceptive pain experienced by your body, which is caused by the stimulation of pain receptors.

Now imagine that you see a friend injure him or herself in the same way. You would again literally wince and feel pain, empathetic pain in this case. Although you yourself have not sustained any injury, to some extent you would experience the same symptoms: You would feel anxiety; you may recoil to put distance between yourself and the source of the pain; and you would store information about the context of the experience in order to avoid pain in the future.

Activity in the brain

Previous studies have shown that the same brain structures – namely the anterior insula and the cingulate cortex – are activated, irrespective of whether the pain is personally experienced or empathetic. However, despite this congruence in the underlying activated areas of the brain, the extent to which the two forms of pain really are similar remains a matter of considerable controversy.

To help shed light on the matter, neuroscientists, including Tania Singer, Director at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, have now proposed a new theory: “We need to get away from this either-or question, whether the pain is genuine or not.”

Instead, it should be seen as a complex interaction of multiple elements, which together form the complex experience we call “pain”. The elements include sensory processes, which determine, for example, where the pain stimulus was triggered: in the hand or in the foot? In addition, emotional processes, such as the negative feeling experienced during pain, also come into play. “The decisive point is that the individual processes can also play a role in other experiences, albeit in a different activation pattern,” Singer explains – for example, if someone tickles your hand or foot, or you see images of people suffering on television. Other processes, such as the stimulation of pain receptors, are probably highly specific to pain. The neuroscientists therefore propose comparing the elements of direct and empathetic pain: Which elements are shared and which, by contrast, are specific and unique to the each form of pain?

Areas process general components

A study that was published almost simultaneously by scientists from the Max Planck Institute for Human Cognitive and Brain Sciences and the University of Geneva has provided strong proof of this theory: They were able to demonstrate for the first time that during painful experiences the anterior insula region and the cingulate cortex process both general components, which also occur during other negative experiences such as disgust or indignation, and specific pain information – whether the pain is direct or empathic.

The general components signal that an experience is in fact unpleasant and not joyful. The specific information, in turn, tells us that pain – not disgust or indignation – is involved, and whether the pain is being experienced by you or someone else. “Both the nonspecific and the specific information are processed in parallel in the brain structures responsible for pain. But the activation patterns are different,” says Anita Tusche, also a neuroscientist at the Max Planck Institute in Leipzig and one of the authors of the study.

Thanks to the fact that our brain deals with these components in parallel, we can process various unpleasant experiences in a time-saving and energy-saving manner. At the same time, however, we are able register detailed information quickly, so that we know exactly what kind of unpleasant event has occurred – and whether it affects us directly or vicariously. “The fact that our brain processes pain and other unpleasant events simultaneously for the most part, no matter if they are experienced by us or someone else, is very important for social interactions,” Tusche says, “because it helps to us understand what others are experiencing.”

When my alcoholic uncle died - and how it impacted my life as a nurse

A recent post from another nurse was so beautifully honest and vulnerable that it made me lose my snark and just get human for a minute. So I will share an experience and I have permission from all involved. I had an uncle who was a terrible alcoholic. It ravaged every aspect of his life, his work as a union tradesman, his ability to be a father or husband and his relationships with his brothers and sisters. My mom and I often visited him when he’d get admitted to the floor. I could never bear to see him in the ER. Dirty, belligerent, withdrawing in the DTs. I was embarrassed because I knew he was a frequent flier. I was embarrassed that I was embarrassed. We tried to drop him groceries and buy his Dilantin every month, but he moved around a lot, mostly renting rooms above taverns. He wanted nothing to do with sobriety. He used drugs when he could, but whiskey was his poison. In the end he only tolerated a few beers a day to keep away the shakes. To any nurse or medic or doc who new him he was a local drunk, but to me he was my uncle. I knew him as a kind loving man as well. I remember family BBQs and him tossing me up in the air as a kid. I remember him showing up drunk to thanksgiving and not making it out out of the car before passing out. I remember the disappointment in my family’s faces. I remember the shame in his eyes. I remember driving around his neighborhood looking at the entrances of taverns to see if he was passed out. I wondered if anyone would know to call us if he died. I wondered if he even had any I.D. But they did call. And I knew when I saw him at age 55 in the ICU Weighing 90 lbs dying of Hep C and esophageal CA that he didn’t have a lot of time left. I was a nursing student and an ER tech but I knew in my heart this time was different. I saw people fear him. I saw nurses treat him as if he was a leper. One yelled at him to be still while she gave him a shot of heparin and he grimaced in pain. Nurses came in one by one to start a heplock and he grimaced in pain. Despite knowing better after the 4th nurse was unsuccessful I begged them to stop and give him a break. My hospital I worked accepted him into impatient hospice. I was relieved. When he arrived I saw the 2 EMTs toss him on the hospice bed and walk out without saying a word while he grimaced in pain. They probably got held over and he probably didn’t seem like an urgent transport. They didn’t want to touch him. I didn’t say anything. I was scared to touch him too. He was emaciated with a huge head and a gaunt appearance. I wondered if he had AIDS. I felt bad for thinking that. I still kissed his forehead and told him he was going to be okay. Because I loved him. He was my family. And then I saw nurses treat him with kindness. I saw the beauty of a non judgemental hospice team make his last 96 hours on Earth a time where he could make peace with his demons. I saw Roxy drops for the first time and I saw him get some relief from the pain of untreated cancer, from the pain of dying. I saw them allow me break the rules and lift his frail body into a wheelchair, fashion an old fashioned posey to hold him up and take him down stairs for his last cigarette on Route 30. I was able to spend my breaks with him. I got to suction him and help give him a bed bath. I got off my 3-11 shift and spend a few hours with him watching a baseball game on replay. I sat with him in silence and I held his hand. I finally knew what people meant when they said the dying watch their life play out in their minds. I swear I could see it happening. I asked him if he was thinking about things he said “yep”. I asked him if he wanted me to stay or go and he said “stay”. So I stayed. I heard the death rattle for the first time. I cried to a veteran hospice nurse and she explained how the Scopolamine patch would help. I finally felt what it was like to be helpless to a family member in need and her words of comfort and years of experience meant everything to me. She said he probably had 48 hours at the most. I read “Gone from my sight” the blue book of hospice by Barbara Karnes. The whole family trickled in. His kids, all his brothers and sisters and nieces and nephews. His children told him they loved him and they forgave him. We kissed his forehead and washed his hair. My mother shaved his face. His daughter said words of kindness that relieved him of any guilt or regret. I saw this beautiful cousin of mine watch me suction him and she asked how I could be so calm and so strong. I didn’t feel strong or knowledgeable but when you are the “medical person” in the family they see things in you that you didn’t know you had. We surrounded him with love and light and he died surrounded by everyone who ever meant anything to him. The nurses even cried. I got to see the dying process for what it was. It was beautiful and at the same time so humbling it brought me to my knees. I have never forgotten that feeling and I pray I never do. Is alcoholism a disease? We debate it as health care providers and wonder about the others whose lives have been impacted by the actions of an alcoholic. The amends that never got made. I guess I don’t care if it’s a disease, a condition, or a lifetime of conscious choices and poor judgement. In the end it’s a human being, usually a dirty foul smelling human being with missing teeth who may or may not be soiled in urine and vomit. Sometimes kicking, hurling obscenities, racial slurs, or spitting. Often doing all of the above at once. It’s hard to empathize with a human being who arrives packaged up that way. It’s hard to care or to want to go above and beyond. And I don’t think you should ever feel guilty if you don’t have those feelings. That is okay. It’s natural to wonder about the damage these people may have done to others. Wonder how many lives they might have ravaged. Please don’t take their pain as your own. At least try not to. It is not your pain to carry. And we all know that is easier said than done. But please, Treat them with dignity. They feel. They hear you. Give them the care you know you are capable of giving. I can tell you I hold a special place in my heart for every nurse who touched my uncle with a gentle hand. Who cleaned him for the fifth time when he was vomiting stool. Who asked him to smile. Who smiled back at him. Who stroked his forehead and put a cool washcloth on it. I am eternally grateful for anyone that saw beyond his alcoholism and saw a person. A human. A child of God (if you believe in God). A father. A son. An uncle. And I believe in my heart he felt the same way, even if he didn’t or couldn’t say it. If you have that patient. That difficult, hard to like, dreadful patient. Don’t think you have to love them or even like them. You don’t. But if you can preserve their dignity and show them the kind of nursing care that anyone would deserve, than you are good. You are the reason we are the world’s most trusted profession. And even though you don’t know it, someone saw and felt it, and it meant the world to them. Go to bed and sleep soundly because you deserve that. - J.R. RN

Farming amoebae carry around detoxifying food

Five years ago, the Queller-Strassmann lab at Rice University, now at Washington University in St. Louis, demonstrated that the social amoeba Dictyostelium discoideum – affectionately nicknamed “Dicty” – can maintain a crop of food bacteria from generation to generation, giving these farmers an advantage when food is scarce.

Now, new research from the same team shows that these microscopic farmers also rely on their symbiotic bacteria to protect themselves from environmental toxins, a little-studied but increasingly clear role microbes can play for their hosts.

Research scientist Debra Brock led the new work, published April 20 in the Proceedings of the Royal Society B.

These amoebae are content to be loners when food is abundant, but when it’s depleted they come together in the tens of thousands to cooperate. They transform into a mobile slug that migrates in search of fairer conditions and then produces hardy spores to release into the environment and wait out the lean times.

The slug has a tiny pool of specialized cells, called sentinels, that protect it from pests and poisons by ferrying them away.

“The sentinel cells pass through the body, mopping up toxins, bacteria, and essentially serving as a liver, a kidney, and innate immune system and being left behind in the slime trail,” said Joan Strassmann, PhD, the Charles Rebstock Professor of Biology in Arts & Sciences.

Debra A. Brock, W. Éamon Callison, Joan E. Strassmann, David C. Queller. Sentinel cells, symbiotic bacteria and toxin resistance in the social amoebaDictyostelium discoideum. Proceedings of the Royal Society B: Biological Sciences, 2016; 283 (1829): 20152727 DOI: 10.1098/rspb.2015.2727

The social amoeba Dictyostelium discoideum has both solitary and communal life stages. As long as food is abundant, it lives on its own, but when food is scarce the amoebae seek one another out. Together they form a slug that migrates toward the light and then a fruiting body that disperses spores from atop a stalk. The fruiting bodies are pictured here. Credit: Strassmann/Queller lab

Sasando

pic: wikipedia

The sasando is a harp-like musical instrument from East Nusa Tenggara, Indonesia, specifically in the island of Rote. The name is derived from the Rote dialect word “sasandu” meaning “vibrating or sounded instrument.” It can have 28 or 56 strings.

There’s a folktale that explained the origins of the sasando. Once, there was a boy called Sangguana who lived in Rote. One day, he was tired and fell asleep under a palmyra tree, and dreamt that he played beautiful music with a unique instrument that made an enchanting sound. When he woke up, Sangguana was able to vividly remember the melody he played in the dream. He wanted to hear it once more, so he slept again, and dreamt of the same song and the same instrument. Sangguana had to wake up, eventually, but, not wanting to lose the instrument from his dream, he made an instrument out of palmyra leaves based on the one he saw in his dream, which became the basis for the sasando.

if you want to see how it sounds: (start 0:30)

I am pretty sure that this cannot be true because I saw an ad from the corn industry that said high fructose corn syrup is good for you…

Fructose alters hundreds of brain genes, which can lead to a wide range of diseases

A range of diseases – from diabetes to cardiovascular disease, and from Alzheimer’s disease to attention deficit hyperactivity disorder – are linked to changes to genes in the brain. A new study by UCLA life scientists has found that hundreds of those genes can be damaged by fructose, a sugar that’s common in the Western diet, in a way that could lead to those diseases.

However, the researchers discovered good news as well: An omega-3 fatty acid known as docosahexaenoic acid, or DHA, seems to reverse the harmful changes produced by fructose.

“DHA changes not just one or two genes; it seems to push the entire gene pattern back to normal, which is remarkable,” said Xia Yang, a senior author of the study and a UCLA assistant professor of integrative biology and physiology. “And we can see why it has such a powerful effect.”

Qingying Meng, Zhe Ying, Emily Noble, Yuqi Zhao, Rahul Agrawal, Andrew Mikhail, Yumei Zhuang, Ethika Tyagi, Qing Zhang, Jae-Hyung Lee, Marco Morselli, Luz Orozco, Weilong Guo, Tina M. Kilts, Jun Zhu, Bin Zhang, Matteo Pellegrini, Xinshu Xiao, Marian F. Young, Fernando Gomez-Pinilla, Xia Yang. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. EBioMedicine, 2016; DOI: 10.1016/j.ebiom.2016.04.008

Americans get most of their fructose in foods that are sweetened with high-fructose corn syrup, an inexpensive liquid sweetener made from corn starch, and from sweetened drinks, syrups, honey and desserts. The Department of Agriculture estimates that Americans consumed an average of about 27 pounds of high-fructose corn syrup in 2014.  Credit: © AlenKadr / Fotolia

Breakthrough on ash dieback

UK scientists have identified the country’s first ash tree that shows tolerance to ash dieback.

Ash dieback is spreading throughout the UK and in one woodland in Norfolk, a great number of trees are infected. 

The team compared the genetics of trees with different levels of tolerance to ash dieback disease. From there, they developed three genetic markers which enabled them to predict whether or not a tree is likely to be tolerant to the disease. One tree named Betty, they discovered, was predicted to show strong tolerance.

The findings raise the possibility of using selective breeding to develop strains of trees that are tolerant to the disease to help safeguard our forests. 

Read more

Images: Close-up infected ash petioles (leaf stems) - Copyright: John Innes Centre

Image: The libertine Falstaff sits with a woman on his lap and a tankard in his hand in an illustrated scene from one of William Shakespeare’s Henry IV plays. (Kean Collection/Getty Images)

The eggplant and peach emoji are standard code for racy thoughts these days, but people have been using food as sexual innuendo for centuries. In fact, William Shakespeare was a pro at the gastronomic double entendre [insert blushing face emoji here]. The Salt blog asked a Shakespeare expert to help them decode some of the bard’s bawdy food jokes. (And the result is delightful. – Nicole)

50 Shades Of Shakespeare: How The Bard Used Food As Racy Code

Sleep suppresses brain rebalancing

Why humans and other animals sleep is one of the remaining deep mysteries of physiology. One prominent theory in neuroscience is that sleep is when the brain replays memories “offline” to better encode them (“memory consolidation”). A prominent and competing theory is that sleep is important for re-balancing activity in brain networks that have been perturbed during learning while awake. Such “rebalancing” of brain activity involves homeostatic plasticity mechanisms that were first discovered at Brandeis University, and have been thoroughly studied by a number of Brandeis labs including the Turrigiano lab. Now, a study from the Turrigiano lab just published in the journal Cell shows that these homeostatic mechanisms are indeed gated by sleep and wake, but in the opposite direction from that theorized previously: homeostatic brain rebalancing occurs exclusively when animals are awake, and is suppressed by sleep. These findings raise the intriguing possibility that different forms of brain plasticity – for example those involved in memory consolidation and those involved in homeostatic rebalancing – must be temporally segregated from each other to prevent interference.

The requirement that neurons carefully maintain an average firing rate, much like the thermostat in a house senses and maintains temperature, has long been suggested by computational work. Without homeostatic (“thermostat-like”) control of firing rates, models of neural networks cannot learn and drift into states of epilepsy-like saturation or complete quiescence. Much of the work in discovering and describing candidate mechanisms continues to be conducted at Brandeis. In 2013, the Turrigiano Lab provided the first ­in vivo evidence for firing rate homeostasis in the mammalian brain: lab members recorded the activity of individual neurons in the visual cortex of freely behaving rat pups for 8h per day across a nine-day period during which vision through one eye was occluded. The activity of neurons initially dropped, but over the next 4 days, firing rates came back to basal levels despite the visual occlusion. In essence, these experiments confirmed what had long been suspected – the activity of neurons in intact brains is indeed homeostatically governed.

Due to the unique opportunity to study a fundamental mechanism of brain plasticity in an unrestrained animal, the lab has been probing the possibility of an intersection between an animal’s behavior and homeostatic plasticity. In order to truly evaluate possible circadian and behavioral influences on neuronal homeostasis, it was necessary to capture the entire 9-day experiment, rather than evaluate snapshots of each day. For this work, the Turrigiano Lab had to find creative computational solutions to recording many terabytes of data necessary to follow the activity of single neurons without interruption for more than 200 hours. Ultimately, these data revealed that the homeostatic regulation of neuronal activity in the cortex is gated by sleep and wake states. In a surprising and unpredicted twist, the homeostatic recovery of activity occurred almost exclusively during periods of activity and was inhibited during sleep. Prior predictions either assumed no role for behavioral state, or that sleeping would account for homeostasis. Finally, the lab established evidence for a causal role for active waking by artificially enhancing natural waking periods during the homeostatic rebound. When animals were kept awake, homeostatic plasticity was further enhanced.

This finding opens doors onto a new field of understanding the behavioral, environmental, and circadian influences on homeostatic plasticity mechanisms in the brain. Some of the key questions that immediately beg to be answered include:

What it is about sleep that precludes the expression of homeostatic plasticity?

How is it possible that mechanisms requiring complex patterns of transcription, translation, trafficking, and modification can be modulated on the short timescales of behavioral state-transitions in rodents?

And finally, how generalizable is this finding? As homeostasis is bidirectional, does a shift in the opposite direction similarly require wake or does the change in sign allow for new rules in expression?

Researchers can identify you by your brain waves with 100 percent accuracy

Your responses to certain stimuli – foods, celebrities, words – might seem trivial, but they say a lot about you. In fact (with the proper clearance), these responses could gain you access into restricted areas of the Pentagon.

A team of researchers at Binghamton University, led by Assistant Professor of Psychology Sarah Laszlo and Assistant Professor of Electrical and Computer Engineering Zhanpeng Jin, recorded the brain activity of 50 people wearing an electroencephalogram headset while they looked at a series of 500 images designed specifically to elicit unique responses from person to person – e.g., a slice of pizza, a boat, Anne Hathaway, the word “conundrum.” They found that participants’ brains reacted differently to each image, enough that a computer system was able to identify each volunteer’s “brainprint” with 100 percent accuracy.

“When you take hundreds of these images, where every person is going to feel differently about each individual one, then you can be really accurate in identifying which person it was who looked at them just by their brain activity,” said Laszlo.

In their original study, titled “Brainprint,” published in 2015 in

Neurocomputing

, the research team was able to identify one person out of a group of 32 by that person’s responses, with only 97 percent accuracy, and that study only incorporated words, not images

Maria V. Ruiz-Blondet, Zhanpeng Jin, Sarah Laszlo. CEREBRE: A Novel Method for Very High Accuracy Event-Related Potential Biometric Identification. IEEE Transactions on Information Forensics and Security, 2016; 11 (7): 1618 DOI: 10.1109/TIFS.2016.2543524

Woman wearing an EEG headset.Credit: Jonathan Cohen/Binghamton University