Purple-backed Thornbill (Ramphomicron Microrhynchum), Male, Family Trochilidae, Order Apodiformes, Colombia

bolting upright with a drawing idea as if i have the energy to do anything but sneeze

Quick! Download those animes from the Internet Archive before a copyright claim takes them down.

whimsy is a virtue I think. one of the more important ones, especially if you're about to embark on a serious undertaking. and when things are getting distinctly unwhimsical in a situation it's generally a sign you ought to make yourself scarce.

TIL: early movable-type printers would store the normal letters in a case on a bottom shelf, and the capital letters in another case on a top shelf, and that’s where the terms “upper case” and “lower case” come from.

I've said it before, and I'll say it again: one of the only few bad things about Tolkien's legendarium is that it makes 90% of all other fantasy worlds look either completely or somewhat mediocre in comparison.

Like, what do you mean you don't have a fictional language for your fantasy world? WEAKLINGS

you used to be able to put a dvd in your laptop and play it. you used to be able to burn cds.

Petition for more websites to have a policy like Wikipedia, e.g., where anyone can easily download an entire copy of the site for offline use.

One of the funniest things about communism is that it rests on a premise that's basically like, "Hey, once everybody voluntarily gives up a specific set of strategies and advantages, everything will be wonderful. So, once we figure out how to coerce everybody into voluntarily giving those up, we'll be set."

Completely sober in the club googling worst medieval executions

Macrophage Defector

Natural killer cells are a type of immune cell that protects the body against not only invading pathogens but also cancer, providing an innate defence against these rogue cells. Some tumours, however, keep natural kill cells at bay and thereby avoid destruction. And recent research in lung tumours reveals this natural killer cell exclusion is achieved with the help of another immune cell – the macrophage. The particular culprit is a type of macrophage covered in a protein called TREM2 – an anti-inflammatory factor. Shown above is a lung tumour (green) packed with TREM2-expressing macrophages (red) that are protecting the cancer from attack. Why these macrophages switch allegiance and side with enemy is unclear, but blocking TREM2 while boosting natural killer cell activity was shown to reduce lung tumour growth in mice suggesting a similar approach might be effective in promoting tumour regression in humans too.

Written by Ruth Williams

Image from work by Matthew D. Park and Ivan Reyes-Torres, and colleagues

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Image copyright held by the original authors

Research published in Nature Immunology, April 2023

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