One Bummer Revelation From This Most Recent Business Trip Is That I May Have Reached A Point In My Career

When you die and go to the afterworld, you get to sneeze all of the sneezes you sneezed, again -- as well as all the sneezes you didn't get to sneeze.

Macrophage Defector

Natural killer cells are a type of immune cell that protects the body against not only invading pathogens but also cancer, providing an innate defence against these rogue cells. Some tumours, however, keep natural kill cells at bay and thereby avoid destruction. And recent research in lung tumours reveals this natural killer cell exclusion is achieved with the help of another immune cell – the macrophage. The particular culprit is a type of macrophage covered in a protein called TREM2 – an anti-inflammatory factor. Shown above is a lung tumour (green) packed with TREM2-expressing macrophages (red) that are protecting the cancer from attack. Why these macrophages switch allegiance and side with enemy is unclear, but blocking TREM2 while boosting natural killer cell activity was shown to reduce lung tumour growth in mice suggesting a similar approach might be effective in promoting tumour regression in humans too.

Written by Ruth Williams

Image from work by Matthew D. Park and Ivan Reyes-Torres, and colleagues

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Image copyright held by the original authors

Research published in Nature Immunology, April 2023

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have you considered that it's you who is old, and not the email draft?

While I was typing up some documents this afternoon, I needed a throwaway email address to receive some information.

So I logged into an older account I have, then clicked the drafts folder. I found a draft of an email from 2017.

The body read, "This email will have to wait." I guess I must have been hyperliteral at the time, since it's now been waiting for eight years.

Sonja Vordermaier; installation, Street Lamp Forest.

It's still so strange to me how apparently taboo it is to like a post on someone's Instagram from a month ago when there are posts still circulating on Tumblr from 1550 BCE

Some of you are cool and deserve to be let inside the secret group chat.

One of the most boring forms of discourse is when two opposing sides are like, "They're hypocrites!" "No, they're the hypocrite!"

The loss of “lurk moar” has really ruined the youth culture because under any clip or meme you’ll see kids commenting “context?” even if it is eminently googleable.

*through gritted teeth* it doesn’t have to be perfect, it just has to be done. it doesn’t have to be perfect, it just has to be done. it doesn’t have to be-

Stop excluding me from your secret clubs.