I Need To Make A Shoutout Post For The Ioway Tribe's Bee Farm Products Right Now

New posepack: Spellcasters

A while ago I started making these poses for a character of mine, although he didn’t need them in the end (which is why there will, at some point, be a version of these with a walking stick instead). BUT it got me thinking that there aren’t many (any?) magic poses for spellcasters who use wheelchairs, so I finally got round to finishing it up.

The first four poses have four different emotions (neutral, angry, sad, happy - just basic stuff) and then the rest are just some random ones that I felt like doing.

You will need: - Windkeepers Modern Wheelchair by @teabaker  - Book by @inabadromance for pose 7

TOU: please don’t steal, redistribute, put behind a paywall, or alter (beyond basic tweaking) in renders thank yooouuu. These are free my dudes, play nicely.

Download here (CurseForge) or alternative download here (SFS) Like my poses? You can now buy me a coffee! 

I’d love to see what you do with them so feel free to tag me here, on Twitter, or Instagram.

@ts4-poses

My mentor: I wanna do a wall garden, because it doesnt take up too much space

Me, already vibrating from the dopamine and adrenaline: Let's talk about espaliers

You know, something that never sat quite right with me is the defense of Bells Hells constantly having the same argument as "realistic" not just because "realistic" doesn't mean "compelling to watch"...but also because this isn't actually realistic in like, functional groups.

I was involved in a number of clubs in college and was on the board of several; I am on an alumni board for a university club I was in as an undergrad. I've been in a leadership role in an independent congregation and a member of several political interest groups in adulthood. I've also been an indirect manager (think team lead for a specific project but not the person people report to regularly) in a professional setting - and those are just formalized settings and not just hanging out with friends or smaller group projects.

The idea that it's normal and relatable to have a group of people who just endlessly and repeatedly provide their perspective and argument without any sort of resolution is one of those "wait, you live like this?" moments. During debates, such as for board elections or in one case, a very emotionally heightened decision to eject a member who had been credibly accused of wrongdoing against another, the phrase that got used once everyone had had a chance to talk and address any questions was, essentially, "will further discussion change anyone's mind." Because that is ultimately the purpose of discussion - to make sure everyone has all the information, and to allow everyone an opportunity to speak their piece in the service of ultimately coming to a decision. Discussion about a course of action is not an end point in itself, and there comes a time where you have to say "your feelings are valid but your talking isn't going to change anyone's mind at this point and we need to move forward in some manner."

Romanticizing endless tiresome indecision feels no different to me than romanticizing some other utterly unnecessary behavior like, I don't know, hustle culture. If your friends can't decide on a restaurant for 2 hours (or 2 months) then either do a rotating schedule, decide to meet for coffee/drinks/a bring-your-own-stuff picnic, or if this is food as part of a longer outing, don't be afraid to split up for a small part of it. If you can't decide what to do in a group project, assign a leader or take it to a vote and provide a clear tie-break condition. Flip a coin, if nothing else can be done. But you do not have to live like this; really, it just takes one person to speak up and say "we've been talking in circles for two hours and I'm exhausted; does anyone have new information or a concern that wasn't brought up or is it time to call it?" And your life will be immeasurably better the day you decide to be that person whenever relevant.

Today my professor picked up a garter snake, said “Ow!” five times as it bit him, set it back down, and said, “Okay. That’s one defense mechanism snakes have.”

Pharmacology Unveiled: How Medications Work on a Molecular Level"

Explore the science of pharmacology and delve into the mechanisms of action of commonly prescribed medications, shedding light on how they interact with the body's systems.

In the multifaceted domain of pharmacology, an intricate symphony of molecular interactions orchestrates the therapeutic effects of medications. A profound comprehension of the molecular underpinnings of pharmacological actions is indispensable for healthcare professionals, pharmaceutical scientists, and researchers. In this discourse, we embark on a comprehensive exploration of pharmacodynamics, elucidating the profound intricacies of how medications function at the molecular level.

Pharmacodynamics: A Multilayered Discipline

Pharmacodynamics constitutes the extensive scrutiny of the manner in which drugs interlace with specific molecular targets, often referred to as receptors or enzymes, within the human organism. Medications are meticulously designed to effectuate alterations in biochemical pathways, receptor kinetics, or enzymatic processes, aiming to modulate physiological phenomena to alleviate symptoms or remediate pathological states.

Receptor-Mediated Pharmacological Actions

A pivotal facet of pharmacodynamics lies in the receptor-mediated actions of medications. Receptors are intricate protein entities, frequently situated on the extracellular or intracellular domains of cells, that play a pivotal role in cellular communication and homeostasis. When a medication interfaces with a receptor, it initiates a cascade of molecular events, which, contingent upon the context, may potentiate or impede the cellular response.

Agonists and Antagonists: Puppets of Molecular Dance

In the intricate theater of pharmacodynamics, medications assume roles as either agonists or antagonists. Agonists aptly mimic the endogenous ligands or signaling molecules, seamlessly integrating into the receptor's binding pocket. This engagement sets forth a conformational alteration in the receptor, instigating cellular events replicating or augmenting the physiological response. Conversely, antagonists function as molecular antagonists, obstructing the receptor and forestalling the binding of endogenous signaling molecules. Consequently, the physiological response is negated or attenuated.

Enzymatic Interference: Orchestrating Biochemical Concertos

Certain medications orchestrate their therapeutic influence through the intricate domain of enzyme inhibition. Enzymes are the catalytic workhorses governing biochemical transformations in biological systems. Medications that selectively inhibit or modulate these enzymes effectively regulate the pace or character of these metabolic reactions, rendering them invaluable in conditions characterized by aberrant enzyme function.

Ion Channel Choreography: Modulating Electrophysiological Ballets

A notable mechanism of pharmacological action entails the modulation of ion channels. These proteinaceous conduits, reposing within cellular membranes, govern the flux of ions across these barriers. Medications designed to engage with ion channels effectively influence the electrochemical signaling within cells. The modulation of ion channels is instrumental in conditions such as arrhythmias, epilepsy, and neuropathic pain.

Pharmacogenetics: Personalizing Medication Regimens

The burgeoning realm of pharmacogenetics delves into the impact of an individual's genetic repertoire on their medication response. Genetic polymorphisms can significantly influence drug metabolism, receptor sensitivities, and pharmacological efficacy. Tailoring medication regimens to align with an individual's genetic makeup represents a burgeoning paradigm in personalized medicine.

Pharmacology unfolds as an intricate tapestry of molecular engagements and multifarious mechanisms. Medications, hewn with precision, are intended to engage with specific molecular entities, be it receptors, enzymes, or ion channels, aiming to modulate intricate biochemical processes to achieve therapeutic ends.

References

Rang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2015). Rang & Dale's Pharmacology. Elsevier.

Katzung, B. G., & Trevor, A. J. (2021). Basic & Clinical Pharmacology. McGraw-Hill Education

Brunton, L. L., Knollmann, B. C., & Hilal-Dandan, R. (2020). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. McGraw-Hill Education.

Science Friday

Trees And Shrubs Are Burying Prairies Of The Great Plains

A “green glacier” of trees and shrubs is sliding across the region, burying some of the most threatened habitat on the planet.

Excerpt from this story from Science Friday:

Flint Hills rancher Daniel Mushrush estimates that his family has killed maybe 10,000 trees in the past three years.

It’s a start. But many more trees still need to fall for the Mushrushes to save this 15,000 acres of rare tallgrass prairie.

Whenever other work on the property can wait, Daniel and his brother, Chris, don helmets and earplugs, grab their tools and pick up where they left off.

“It’s a lot of old-fashioned chainsaw work,” Daniel Mushrush said. “Walking rocky ridges and cutting down trees.”

The Mushrush family is beating back a juggernaut unleashed by humans — a Green Glacier of trees and shrubs grinding slowly across the Great Plains and burying some of the most threatened habitat on the planet.

This blanket of shrublands and dense juniper woods gobbling up grassland leads to wildfires with towering flames that dwarf those generated in prairie fires.

It also eats into ranchers’ livelihoods. It smothers habitat for grassland birds, prairie fish and other critters that evolved for a world that’s disappearing. It dries up streams and creeks. New research even finds that, across much of the Great Plains, the advent of trees actually makes climate change worse.

Now a federal initiative equips landowners like Mushrush with the latest science and strategies for saving rangeland, and money to help with the work.

Satellite imagery and a better understanding of how trees and shrubs spread could help landowners replace a losing game of whack-a-mole with a more systematic course.

Mushrush calls the approach, promoted by the Natural Resources Conservation Service’s Great Plains Grassland Initiative with guidance from the University of Nebraska-Lincoln, a morale builder.

“It works,” the third-generation rancher said. “We’re still overwhelmed with how to do this on 15,000 acres — but we have a plan.”

Each time he thinks about the Manhattan area, which is much more infested with juniper woods and seas of sumac, wild plum and dogwood thickets, he feels the threat creeping toward his home in Chase County.

“If a coral reef is worth saving, if some pristine mountain stream is worth saving, then so are the Flint Hills,” he said. “It’s not easy work, but it’s worthy work.”

🌷 FREJA NURSERY

Happy New Year!

Meet FREJA NURSERY – a collection of (somewhat random) functional and decorative nursery items. This set began with the hanging chair idea which was proposed by one of my patrons, and it grew into this boho-vibes collection. This time I also made a little preview video with the objects – so excited to finally share it!

Here’s what you get:

Hanging chair (3 different heights), 30 swatches, 600§

Hanging herbs and flowers (3 different heights), 4 swatches, 300§

Toddler bed frame, 8 swatches, 200§

Toddler bed mattress, 12 swatches, 200§

Dresser, 8 swatches, 600§

Wicker pouf, 30 swatches, 200§

Suitcases (end table), 6 swatches, 200§

Faux fur rug, 10 swatches, 300§

Décor - tapestry, 6 swatches, 350§

Décor - crib, 30 swatches, 250§

Some more info & credits:

Base game compatible

New meshes, all LODs

Custom specular & normal maps

Custom catalog thumbnails, tagged swatches

Credit to Spirashun for the separated toddler bedframes and mattresses which I used as a base. Thank you!

Swatches come from my personal palette & from @peacemaker-ic Cool Contemporary palette

Wicker and fur textures are created by me in Procreate, Adobe Illustrator and Adobe Photoshop

You can search for "freja" or "myshunosun" in the buy catalog to quickly access these items. I am so excited for you to try this set out – enjoy! Wishing you a happy 2022!

🌷 DOWNLOAD (+ in-game preview, free)

🌷 Follow & support me here: tumblr / twitter / patreon / youtube

@maxismatchccworld @s4library @sssvitlanz @mmfinds

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UPDATE 03.01.2021: the medium height hanging chair now has the correct mesh height. Please re-download the file and replace it in your Mods folder! :)

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UPDATE 07.01.2021: I noticed that the hanging chairs aren't displayed correctly when zoomed out, or if you're playing the game on lower graphics settings. The issue is now fixed - please re-download the files :)

Moonwood Garden

Moonwood Garden includes 13 items for all your gardening needs. Decorate your garden, grab some seeds from your new garden workbench and plant some herbs in a compact 2-tile planter box. You can read more about the items, find the in-game preview and download the set below!

Download set (always free on Patreon) / Follow me on social media

@maxismatchccworld @s4library @sssvitlanz @public-ccfinds @mmfinds

Here's what you get:

2-tile planter box*, 14 swatches, 75§   

4-tile planter box, 14 swatches, 100§   

Flower arranging table (Seasons EP required to function), 14 swatches, 250§   

Base game table (functions as display), 14 swatches, 250§ 

Box with pots, 8 swatches, 80§ 

Vertical garden (decor), 14 swatches, 150§ 

Ladder shelf, 14 swatches, 150§ 

Picked flowers, 1 swatch, 20§ 

Potted fig plant, 6 swatches, 75§ 

Potted ivy plant, 6 swatches, 50§ 

Bag of garden soil, 6 swatches, 25§ 

Stacked bags of garden soil, 6 swatches, 50§ 

Stack of pots, 5 swatches, 40§ 

Here’s some more info and credits: 

Base game compatible 

New meshes, all LODs 

Custom specular and normal maps 

Custom catalog thumbnails, tagged swatches 

Simlish font is by gazifu 

Swatches come from my personal palette and from peacemaker-ic's color palettes 

* I created new tuning in order to make the 2-tile planter functional. You can plant 2 small plants in it. Let me know if you notice anything strange!

You can search for “moonwood” or “myshunosun” in the buy catalog to quickly access these items. Enjoy! 

Follow and support me here: Tumblr / Twitter / Patreon / Instagram

Not to be a technical writer on main, but I've been bumping into the idea lately that the only reason explaining yourself in more detail never seems to work is because neurotypical people are misunderstanding you on purpose, or because they have short attention spans, or because they just hate listening to you talk – and sure, occasionally that's even true, but most of the time the problem you're running into is more fundamental.

Every time you add more detail, you're running the risk of tripping over a bad assumption on your part about the listener's prior knowledge, or hitting the tipping point where they become overwhelmed with new information (and remember that you don't know which parts of what you're saying will be new information for them), or making a leap of logic that isn't as self-evident as you think it is, or any of a dozen other potential snags which, by definition, you will not see coming until it's too late to correct course.

Basically, every piece of information you add multiplies the odds of you getting blindsided by some vector of misunderstanding you didn't anticipate, even as it addresses the ones you did anticipate. The point of diminishing returns where continuing to elaborate increases the odds of unexpected miscommunication more than it decreases the odds of expected miscommunication is much nearer than you'd like.

The most effective act of communication is not the one which contains the most possible information, but the one which contains the smallest amount of information it possibly can while still getting its point across. It sucks, but it's the reality of the situation. People far more autistic than you have been trying for hundreds of years to invent a way of communicating which doesn't work this way, without success.

All of which is to say that "getting to the damn point" is legitimately a communication skill, not just an accommodation for people who aren't paying attention. If it's any consolation, it's something neurotypical people struggle with just as much as anyone else – if it was easy, technical writers wouldn't have jobs!