Ourvioletdeath - Inner Ramblings Of The Mind

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Please read this if you want to make a sick boy happy. Lorenzo Snippe is a 9-year-old boy from the Netherlands who is very sick. In 2016 he was diagnosed with leukemia and in 2017 with x-ald. On the third (3) of February is his tenth (10) birthday, and it will probably be his last. Because he can’t get any visitors due to being so sick, his parents have asked people in this news article to send him a happy birthday postcard as soon as possible. 

If you’re able to, please send him a postcard wishing him a happy birthday and tell him where you’re from! If you can’t, please reblog this post to make sure it will reach as many people as possible! His address is: 

Prinses Wilhelminastraat 22 

7753 TM Dalerpeel 

The Netherlands 

He really loves animals, so it would be great if you could send a postcard with an animal on it or something like that! 

Don’t send him or his family rude things and don’t use his address for other things than described in this post!

Matteo Farinella.

The Ancient Dragon had awoken, looked over the terrified villagers… and immediately started gushing about how cute they were.

The bassoon causing new brain disorder

Mutations have been found in the bassoon (BSN) gene, which is involved with the central nervous system, in patients with symptoms similar to, but different from, a rare brain disorder called progressive supranuclear palsy (PSP).

PSP, a form of Parkinson’s disease, is often difficult to diagnose because it can affect people in different ways. Serious problems often include difficulty with walking and balance in addition to a decline in cognitive abilities such as frontal lobe dysfunction.

A team of Japanese researchers investigated patients whose symptoms resembled not only PSP but also Alzheimer’s disease. Despite similarities in the symptoms, detailed pathological analyses showed no resemblance to either disease, which prompted the team to further research the new disease’s underlying mechanism.

They first analyzed the genomes of a Japanese family with several members displaying PSP-like symptoms. They identified a mutation in the BSN gene only in family members with symptoms. These individuals did not have mutations in the 52 other genes associated with PSP and other neurological disorders such as Alzheimer’s and Parkinson’s. This was the first time BSN gene is associated with a neurological disorder.

(Image caption: MRI analysis of a patient with PSP-like symptoms showed severe atrophy of the bilateral hippocampus, mesencephalic tegmentum, cerebellum, and brainstem. Credit: Yabe I. et al., Scientific Reports, January 16, 2018)

The researchers also detected three other mutations in the BSN gene in four out of 41 other patients displaying sporadic, or non-familial, PSP-like symptoms. None of the BSN mutations were detected in a random sample of 100 healthy individuals, underscoring the strong involvement of BSN mutations in the disease.

An autopsy done on one of the family members with the BSN mutation showed an accumulation of a protein called tau in the brain, which is not seen in a normal brain. The researchers believe that the BSN mutation is involved in the tau accumulation, which could cause the development of PSP-like symptoms. An experiment introducing a mutated rat BSN gene to cultured cells also suggested that the mutation causes the accumulation of tau. Communication between nerve fibres could also be affected, as BSN protein play a role in it.

(Image caption: Tau proteins accumulated in the brain of a patient with PSP-like symptoms. Credit: Yabe I. et al., Scientific Reports, January 16, 2018)

“This is a peculiar neurodegenerative disorder which involves mutations in the BSN gene and tau accumulation, but differs from any known disease, including dementia, Parkinson’s, and even PSP,” says Associate Professor Ichiro Yabe of Hokkaido University who led the study. “Patients with PSP-like symptoms and other neurodegenerative disorders should be analyzed for BSN mutations to fine-tune their diagnoses.”

Underneath the Sky

Studio Ghibli

(Howl’s Moving Castle, My Neighbor Totoro, Spirited Away, Kiki’s Delivery Service, A Whisper in the Heart)

When you wake up from a long nap and don’t know what year it is.

Video by Barnaby

Yo this would be so lit

people who actually got to party to the songs that came out in 2009-2010 are so lucky too bad i was eleven

Rage

Creative title, right? Probably not to be honest, it sounds like something a hipster would post, or an emotional teenage girl(not being sexist, just providing a cliché example). Nonetheless, I feel rather compelled to put that as the title, mainly because it’s something that I feel pretty often. Not necessarily the anger, but the violent aspect of rage, that nearly uncontrollable violence that builds up inside you, is something that I feel virtually every day. Goodness, I sound so whiny, but I feel like I have to express it somehow or else it’s going to eat away at my emotional health.

I recognize that violence isn’t the answer, but it’s infuriating to be unable to do anything other than think about what you would do to someone who truly deserves to suffer. Of course it sounds rather sociopathic, but there are people to truly need to get whats coming to them from time to time.

It’s hard to describe the feeling I get... it’s a mixture of frustration with anxiety, which produces helplessness and then finally creates the violent urge to hurt someone. I have never done anything under the influence of this urge except for once, which I would rather not get into as I was luckily stopped before things got too far. I learned to control the rage, but the build up of it makes it harder and harder to control. I realized that working out often helps reduce the buildup, but what happens when you don’t have time to work out and you are constantly placed under a lot of stress?  Well, you have several options; blow up, take it out on someone, or take a break.

Of course, the most socially acceptable answer is to take a break, which would usually require going out for some fresh air,  but in more extreme circumstances it could mean take a day or two off from work or school, and that SUCKS. Taking a day off will just add to your workload afterwards, since you’ll have to make up for the time you lost the last day. Conversely, what would happen if you let your rage out? Well, if you let it out on someone else, you could hurt them, both mentally and physically. And just blowing up could get you kicked out of your workplace, and maybe even sent to jail if things get physical.

So what is there to do? This is a problem that I find myself to be facing rather often, and it always feels like a lose-lose situation. Maybe by talking about it things could get better, but who really wants to hear someone bitch about their life? I personally would find that to be extremely boring, and it might not even work! The way I found to be a good reliever is just to write it out, but its taken me several days to put this all into something concise, a so what happens to those people who don’t have the time? I guess they turn to drugs? I’m not really sure to be honest.

Maybe my point got lost while I was blabbering about this whole thing, but what I meant to emphasize was that stress, rage and anger can easily build up in people, and sometimes there really is just no way to relieve it, which is extremely frustrating to me.

Goodness, I wrote way too much... Oh well, it helped me vent, which I guess was the purpose of this. If anyone ever actually reads this, I hope you’ve enjoyed my rather long rant on rage and anger, and I hope it was somehow beneficial to you, in whatever way that may be.

Infectious bacterial diseases and where to find them

You’re teleported to 44 BCE Rome in your everyday street clothes. You’re brought before Caesar and he believes you might be from the future, hoping to bring him fortune. One day he questions you, asking “How Do I Die?”