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Why Number Are The Way They Are

How Printing a 3-D Skull Helped Save a Real One

What started as a stuffy-nose and mild cold symptoms for 15-year-old Parker Turchan led to a far more serious diagnosis: a rare type of tumor in his nose and sinuses that extended through his skull near his brain.

“He had always been a healthy kid, so we never imagined he had a tumor,” says Parker’s father, Karl. “We didn’t even know you could get a tumor in the back of your nose.”

The Portage, Michigan, high school sophomore was referred to the University of Michigan’s C.S. Mott Children’s Hospital, where doctors determined the tumor extended so deep that it was beyond what regular endoscopy could see.

The team members needed to get the best representation of the tumor’s extent to ensure that their surgical approach could successfully remove the entire mass

“Parker had an uncommon, large, high-stage tumor in a very challenging area,” says Mott pediatric head and neck surgeon David Zopf, M.D. “The tumor’s location and size had me question whether a minimally invasive approach would allow us to remove the tumor completely.”

To help answer that question, teams at Mott sought an innovative approach: crafting a 3-D replica of Parker’s skull.

The model, made of polylactic acid, helped simulate the coming operation on Parker by giving U-M surgeons “an exact replica of his craniofacial anatomy and a way to essentially touch the ‘tumor’ with our hands ahead of time,” Zopf says.

Just as important, it also allowed the team to counsel Parker and his family by offering them a look at what lurked within — and, with the test run successfully complete, what would lie ahead.

A ‘pretty impressive’ model

The rare and aggressive tumor in Parker’s nose is known as juvenile nasopharyngeal angiofibroma, a mass that grows in the back of the nasal cavity and predominantly affects young male teens. Mott sees a handful of cases each year.

In Parker’s case, the tumor had two large parts: one roughly the size of an egg and the other the size of a kiwi. The mass sat right in the center of the craniofacial skeleton below the brain and next to the nerves that control eye movement and vision.

“We were obviously concerned about the risks involved in this kind of procedure, which we knew could lead to a lot of blood loss and was sensitive because it was so close to the nerves in his face,” says Karl, who praised the 3-D methodology used to aid his son. “It was pretty impressive to see the model of Parker’s skull ahead of the surgery. We had no idea this was even possible.”

Zopf, working with Erin McKean, M.D., a U-M skull base surgeon, was able to completely remove the large tumor. Kyle VanKoevering, M.D., and Sajad Arabnejad, Ph.D., aided in model preparation.

Through preoperative embolization, the blood supply to the tumor was blocked off the day before surgery to decrease blood loss. A large portion of the tumor was then detached endoscopically and removed through the mouth. The remaining mass under the brain was taken out through the nose.

Doctors took pictures of Parker’s anatomy during the surgery and, later, compared it with pictures from the model. They were nearly identical.

“Words alone can’t express how thankful we are for Parker’s talented team of surgeons at Mott,” says his mother, Heidi. “Parker is back to his old self again.”

Powerful potential

Although medical application of the technology continues to gain attention, it isn’t entirely new. Zopf and Mott teams have used 3-D printing for almost five years.

Groundbreaking 3-D printed splints made at U-M have helped save the lives of babies with severe tracheobronchomalacia, which causes the windpipe to periodically collapse and prevents normal breathing. Mott has also used 3-D printing on a fetus to plan for a potentially complicated birth.  

“We are finding more and more uses for 3-D printing in medicine,” Zopf says. “It is proving to be a powerful tool that will allow for enhanced patient care.”

Based on success in patients such as Parker and continued collaboration, it’s a concept that appears poised to thrive.

“Because of the team approach we’ve established at the University of Michigan between otolaryngology and biomedical engineering, the printed models can be designed and rapidly produced at a very low cost,” Zopf says. “Michigan is one of only a few places in the nation and world that has the capacity to do this.”

Your body is an incredibly bizarre machine.

“What you see is a myosin protein dragging an endorphin along a filament to the inner part of the brain’s parietal cortex which creates happiness. Happiness. You’re looking at happiness.”

My tummy is blushing now. 

People Were Asked: ‘What’s The Coolest Thing Most People Don’t Know About Their Own Body?’

Listening To Music Releases Dopamine In The Brain

Have you ever been listening to a piece of music and experienced   intense pleasure, even chills? Valorie Salimpoor and team (2010)   conducted research that shows that listening to music can release the   neurotransmitter dopamine.

A wide range of music — The researchers used PET   (positron emission tomography) scans, fMRI, and psychophysiological   measures such as heart rate to measure reactions while people listened   to music. The participants provided music that they said gave them   intense pleasure and chills. The range of music varied, from classical, folk, jazz, elecronica, rock pop, tango, and more.

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Source for more facts follow NowYouKno

Women scientists made up 25% of the Pluto fly-by New Horizon team. Make sure you share this, because erasing women’s achievements in science and history is a tradition. Happens every day.

.

http://pluto.jhuapl.edu/News-Center/News-Article.php?page=20150712

I find this table fairly reliable.

Via SMBC

Here are 17 jaw-dropping photos of space that show us just how small we really are:

This photo of the moon and Earth taken from the International Space Station.

A dwarf galaxy, about 11 million light-years away from us.

Earth as seen from the moon in 1968.

A cluster of stars, 20,000 light-years away from Earth.

The first flower grown in the International Space Station, photographed by astronaut Scott Kelly.

Saturn, seen through an infared filter.

These visible “loops” on the surface of the sun can reach up to 15 times the diameter of Earth in height.

The Northen Lights just North of Chicago, viewed from the International Space Station.

The Quintuplet Cluster, located 100 light-years from the center of our galaxy.

Pluto and one of its moons, Charon.

The Great Pyramids of Giza, seen from space.

Astronaut Bruce McCandless maneuvering, untethered, above Earth in 1984.

Galaxy NGC 6240, 400 million light-years away from Earth.

Palomar 12, a cluster of stars on the outskirts of the Milky Way.

The remnants of an exploded star.

New York City, seen from the International Space Station.

And the remains of a supernova whose explosion may have been seen almost 2,000 years ago by Chinese astronomers.

Follow @the-future-now

cyanobacterium: i have made Oxygen

chemotrophs: you fucked up a perfectly good planet is what you did. look at it. it’s all rusty

Slime mold was grown on an agar gel plate shaped like America and food sources were placed where America’s large cities are. 

The result? A possible look at how to best build public transportation. 

I just really like the idea of slime mold on a map of the US. It’s beautiful.

hey guys i think i got a pretty nice tan over the summer, what do you think?

before:

after:

Fascinating, even if you are unable to grasp the mathematical depths, details are for professional thinkers on the field, enjoy the surface, is pretty enjoyable too.

Mathematicians Bridge Finite-Infinite Divide

A surprising new proof is helping to connect the mathematics of infinity to the physical world. (Quanta Magazine)

Images by Lucy Reading-Ikkanda

Why do we not discuss clouds more?

I mean look at that. That’s water.

Flying water.

FLYING

FUCKING

WATER

LIKE WHAT THE FUCK, WHY DO WE EVER STOP TALKING ABOUT THIS

WHAT IS THIS

HOW IS THIS EVEN

AND NOW THE FLYING WATER IS EATING A MOUNTAIN

GOD DAMN, WHAT

If Earth had Saturn’s Rings

From an excellent post by Jason Davis

From Washington, D.C., the rings would only fill a portion of the sky, but appear striking nonetheless. Here, we see them at sunrise.

From Guatemala, only 14 degrees above the equator, the rings would begin to stretch across the horizon. Their reflected light would make the moon much brighter.

From Earth’s equator, Saturn’s rings would be viewed edge-on, appearing as a thin, bright line bisecting the sky.

At the March and September equinoxes, the Sun would be positioned directly over the rings, casting a dramatic shadow at the equator.

At midnight at the Tropic of Capricorn, which sits at 23 degrees south latitude, the Earth casts a shadow over the middle of the rings, while the outer portions remain lit.

via x

This terrifying eel-robot will perform maintenance on undersea equipment

Nope.

In 1898 Nikola Tesla once tricked an entire crowd into believing they could control a toy boat by shouting commands - he had in fact invented Radio Control and was piloting the boat himself.

the drum is filled with hot steam and then sprayed with cold water. the pressure on the outside of the drum is far more than inside. the pressures try to maintain and find balance taking the drum as a casualty.

In an experiment, two ravens had to simultaneously pull the two ends of one rope to slide a platform with two pieces of cheese into reach. If only one of them pulled, the rope would slip through the loops, leaving them with no cheese. Without any training they solved the task and cooperated successfully.

However, when one of the two birds cheated and stole the reward of its companion, the victims of such cheats immediately noticed and started defecting in further trials with the same individual.

“Such a sophisticated way of keeping your partner in check has previously only been shown in humans and chimpanzees, and is a complete novelty among birds.”

Source

(Image caption: In this illustration, a pair of eyeglasses “resolves” distinct serotonin neuron subtypes (shown as brightly colored cells) on a simple map of a region called the raphe in the mouse brain. By viewing serotonin neurons through multiple “lenses”—such as single-neuron and population-scale global gene expression, developmental lineage and anatomy—researchers have revealed diverse subtypes and principles of subtype organization in the brain. Credit: Mallory Rice)

Time for a New Definition

It used to be enough to call a serotonergic neuron a serotonergic neuron.

These brain cells make the neurotransmitter serotonin, which helps regulate mood, appetite, breathing rate, body temperature and more.

Recently, however, scientists have begun to learn that these neurons differ from one another—and that the differences likely matter in dysfunction and disease.

Last year, a team led by Harvard Medical School genetics professor Susan Dymecki defined a subgroup of serotonergic neurons in mice by showing that those cells specifically, among all serotonergic neurons, were responsible for increasing the breathing rate when too much carbon dioxide builds up in the body.

Now, Dymecki and colleagues have taken a first stab at systematically characterizing serotonergic neurons at the molecular level and defining a full set of subtypes, again in mice.

The researchers report in Neuron that serotonergic neurons come in at least six major molecular subtypes defined by distinct expression patterns of hundreds of genes. In many cases, the subtypes modulate different behaviors in the body.

By conducting a cross-disciplinary series of experiments, the researchers found that the subtypes also vary in their developmental lineage, anatomical distribution, combinations of receptors on the cell surface and electrical firing properties.

“This work reveals how diverse serotonin neurons are at the molecular level, which may help to explain how, collectively, they are able to perform so many distinct functions,” said Benjamin Okaty, a postdoctoral researcher in the Dymecki lab and co-first author of the paper.

“To have the list of molecular players that make each of these subtypes different from one another gives us an important handle on learning more about what that cell type does and how we can manipulate only that subtype,” said Dymecki. “It holds enormous therapeutic potential.”

“This is an ancient neurotransmitter system that’s implicated in many different diseases, and it’s starting to be cracked open,” said Morgan Freret, a graduate student in the Dymecki lab and co-first author of the paper. “We can now ask questions in a more systematic way about which serotonergic cells and molecules are important in, for example, pain, sleep apnea or anxiety.”

Crucially, the team also showed that a serotonergic neuron’s gene expression and function depend not only on its location in the adult brain stem, but also on its cellular ancestor in the developing brain.

“Earlier work had shown that you could explore the relationship between a mature neuronal system and the different developmental lineages that gave rise to it, but we had no idea whether it was meaningful,” said Dymecki. “We show that the molecular phenotypes of these neurons track quite tightly to their developmental origin, with anatomy making some interesting contributions as well.”

While the work was done in mice, Dymecki is optimistic that it will be replicated in humans because the serotonergic neuronal system is in a highly conserved region of the brain, meaning it tends to remain consistent across vertebrate species.

Because of this, researchers can look for the same molecular signatures in human tissue and begin to tease apart whether particular subtypes of serotonergic neurons are involved in conditions such as sudden infant death syndrome (SIDS) or autism.

Such research could ultimately reveal previously unknown contributions of the serotonergic neuronal system to disease, inform the development of biomarkers or lead to more targeted therapies.

The team’s findings could also inform stem cell research. “Which subtype of serotonergic neuron are we getting when we use current stem cell protocols?” asked Dymecki. “Can we drive the development of different subtypes? Can we watch how gene expression patterns change over time during development for each subtype?”

Finally, the study provides an example of a highly integrative approach to understanding brain function at multiple scales, “linking genes and gene networks to the properties of single neurons and populations of neuron subtypes, all the way up to the level of animal behaviors,” said Okaty. “I think it’s a useful template going forward. Imagine what we’d learn by applying this approach to all the neurotransmitter systems in the brain.”

What scariest word a nuclear physicist can say?

Oops.

Playing Tetris might help reduce the effects of PTSD. Researchers found that those who played it within 4 hours of seeing traumatic events had fewer flashbacks and intrusive memories. They hope to apply the findings to current treatment, which only deals with the effects after they occur. 

Btw, you can play Tetris online for free. Any time. All the time.

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It always creeps me out...

…that no matter

how close

you get

the pupil

seems to

devour light

like a black hole

it reflects no light

The folks over at NASA just featured this nifty infographic on APOD about detecting objects in the sky:

How to Identify that Light in the Sky

What is that light in the sky?

Perhaps one of humanity’s more common questions, an answer may result from a few quick observations.

Image: HK (The League of Lost Causes)

For example — is it moving or blinking? If so, and if you live near a city, the answer is typically an airplane, since planes are so numerous and so few stars and satellites are bright enough to be seen over the din of artificial city lights.

If not, and if you live far from a city, that bright light is likely a planet such as Venus or Mars — the former of which is constrained to appear near the horizon just before dawn or after dusk.

Sometimes the low apparent motion of a distant airplane near the horizon makes it hard to tell from a bright planet, but even this can usually be discerned by the plane’s motion over a few minutes. Still unsure?

The above chart gives a sometimes-humorous but mostly-accurate assessment. Dedicated sky enthusiasts will likely note — and are encouraged to provide — polite corrections.

source [x]

TYPES OF COLOR-BLINDNESS

1. Normal vision

2.  Deuteranopia 

3.  Tritanopia

4. Monochromacy - An extremely rare type of color-blindness in which sufferers can see only in shades of grey, and perceive no color at all. About 1 in 33,000 people is born with this condition.

(Source)

Class in session as Planet X starts it off with our favorite dense objects: 

Neutron Stars!

http://www.space.com/22180-neutron-stars.html

i think the coolest thing would be to see a new color