Frosty Set ❄️

Look I love unconditional devotion love stories as much as the next person, but there's really something so deliciously raw about conditional devotion.

I have served you and I have loved you for decades, but I will not give up my principles for you. You cut out part of my heart and took it with you down that path that you insist on walking, but you walk it alone. Even when the bleeding, gaping hole you left in my chest kills me, I will not follow you.

watch what happens when I find you.

Pharmacology Unveiled: How Medications Work on a Molecular Level"

Explore the science of pharmacology and delve into the mechanisms of action of commonly prescribed medications, shedding light on how they interact with the body's systems.

In the multifaceted domain of pharmacology, an intricate symphony of molecular interactions orchestrates the therapeutic effects of medications. A profound comprehension of the molecular underpinnings of pharmacological actions is indispensable for healthcare professionals, pharmaceutical scientists, and researchers. In this discourse, we embark on a comprehensive exploration of pharmacodynamics, elucidating the profound intricacies of how medications function at the molecular level.

Pharmacodynamics: A Multilayered Discipline

Pharmacodynamics constitutes the extensive scrutiny of the manner in which drugs interlace with specific molecular targets, often referred to as receptors or enzymes, within the human organism. Medications are meticulously designed to effectuate alterations in biochemical pathways, receptor kinetics, or enzymatic processes, aiming to modulate physiological phenomena to alleviate symptoms or remediate pathological states.

Receptor-Mediated Pharmacological Actions

A pivotal facet of pharmacodynamics lies in the receptor-mediated actions of medications. Receptors are intricate protein entities, frequently situated on the extracellular or intracellular domains of cells, that play a pivotal role in cellular communication and homeostasis. When a medication interfaces with a receptor, it initiates a cascade of molecular events, which, contingent upon the context, may potentiate or impede the cellular response.

Agonists and Antagonists: Puppets of Molecular Dance

In the intricate theater of pharmacodynamics, medications assume roles as either agonists or antagonists. Agonists aptly mimic the endogenous ligands or signaling molecules, seamlessly integrating into the receptor's binding pocket. This engagement sets forth a conformational alteration in the receptor, instigating cellular events replicating or augmenting the physiological response. Conversely, antagonists function as molecular antagonists, obstructing the receptor and forestalling the binding of endogenous signaling molecules. Consequently, the physiological response is negated or attenuated.

Enzymatic Interference: Orchestrating Biochemical Concertos

Certain medications orchestrate their therapeutic influence through the intricate domain of enzyme inhibition. Enzymes are the catalytic workhorses governing biochemical transformations in biological systems. Medications that selectively inhibit or modulate these enzymes effectively regulate the pace or character of these metabolic reactions, rendering them invaluable in conditions characterized by aberrant enzyme function.

Ion Channel Choreography: Modulating Electrophysiological Ballets

A notable mechanism of pharmacological action entails the modulation of ion channels. These proteinaceous conduits, reposing within cellular membranes, govern the flux of ions across these barriers. Medications designed to engage with ion channels effectively influence the electrochemical signaling within cells. The modulation of ion channels is instrumental in conditions such as arrhythmias, epilepsy, and neuropathic pain.

Pharmacogenetics: Personalizing Medication Regimens

The burgeoning realm of pharmacogenetics delves into the impact of an individual's genetic repertoire on their medication response. Genetic polymorphisms can significantly influence drug metabolism, receptor sensitivities, and pharmacological efficacy. Tailoring medication regimens to align with an individual's genetic makeup represents a burgeoning paradigm in personalized medicine.

Pharmacology unfolds as an intricate tapestry of molecular engagements and multifarious mechanisms. Medications, hewn with precision, are intended to engage with specific molecular entities, be it receptors, enzymes, or ion channels, aiming to modulate intricate biochemical processes to achieve therapeutic ends.

References

Rang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2015). Rang & Dale's Pharmacology. Elsevier.

Katzung, B. G., & Trevor, A. J. (2021). Basic & Clinical Pharmacology. McGraw-Hill Education

Brunton, L. L., Knollmann, B. C., & Hilal-Dandan, R. (2020). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. McGraw-Hill Education.

flowers bun

inspired by miley’s hair in her flowers music video

bgc

hat compatible

all 24 ea swatches

dl

So, something I learnt the other day. So, you know how dinosaurs supposedly can't see you if you stand still? Well that myth is based on real-life lizards/etc and how eyes in general work. So, once my dad starts infodumping, here comes some other cool information. We, humans, can in fact, also not see something unless it's moving. We fixed this by having our eyes constantly shake. And then our brain compensates for us, so we don't have to have shaky vision.

What if aliens don't have this? Like. What if they find out when one of us was looking at something in the distance, and they walk around this thing that's in front of them, and the alien is confused so they bob their head and oh, there's a thing there, but how did the human know that, and then we explain and they're like, horrified.

Humans are apex predators. They can hunt in packs. They can hunt in pairs. They can hunt on their own. They're persistance predators, which is unheard of. They get stronger when they're mad or scared. They have this thing called 'body language' which acts like a type of hivemind, even if they'll claim it isn't. And. They can see you. When you're not moving. They can still see you. If you ever find yourself in a fight against a human, for whatever reason? Run. Run as fast as you can. And hope, pray if you have a religion, that they won't follow.

Imagine you got bullied as a kid so to make up for that insecurity you became a super successful alpha male grindset influencer and then one day you got pushed into a portal and found yourself in an alternate universe where you're a malewife who married your old bully. That happened to Luo Bingge

The Coastal Collection - Part One

Happy Friday Everyone!

I’m super excited to be able to share the first part of the Coastal Collection with you all. This has been an absolute labour of love over the course of January to get this first set completed. Never before have I had so many ideas that I wanted to fit into a set & although I couldn’t fit it all into this month I can safely say that there are many more months to come with the set, so I can keep ticking more and more items off the list.

This first month focuses on build items, however there will be a 2nd part to the build items coming next month along with activities for the garden. There are also plans for of course a kitchen, but also a kids set to add to the much anticipated infant patch & new EP releasing in March.

I usually list out all of the items included in the set individually, but there are 55 items and we would be here all week!

In summary the set includes:

22 Windows (Georgian, craftsman & cottage styles)

24 Doors (front doors, cottage doors, French doors, interior doors & archways)

6 Shutters (3 heights, left & right options)

3 Window Boxes (1, 2 & 3 tiles wide)

Early Access Now Available On Patreon

Public Release: 3rd March

🌿MIDSUMMER EVE

Hey everyone! 

Gather your friends and family to spend the warm summer evenings outdoors. MIDSUMMER EVE is a collection of patio items to help you create a perfect space to embrace these lovely summer moments.

Here’s what you get:

Pergola, 20 swatches, 1000§   

Dining table (with tablecloth), 30 swatches, 650§  

Dining table (without tablecloth), 12 swatches, 600§   

Stool, 12 swatches,85§  

Loveseat, 32 swatches, 500§ 

Living chair (with faux fur throw), 32 swatches, 375§ 

Living chair (without faux fur throw), 32 swatches, 350§ 

Coffee table, 12 swatches, 150§ 

Potted citrus tree, 8 swatches, 150§ 

Fruit bowl, 12 swatches, 80§ 

Bag with flowers, 8 swatches, 100§ 

Tray, 12 swatches, 150§ 

Garden lantern, 15 swatches, 100§ 

Here’s some more info and credits: 

Base game compatible 

New meshes, all LODs 

Custom specular & normal maps 

Custom catalog thumbnails, tagged swatches 

Swatches come from my personal palette & from peacemaker-ic's color palettes 

You can search for "midsummer eve" or "myshunosun" in the buy catalog to quickly access these items. Enjoy! 

🌿DOWNLOAD (always free)

🌿 Follow & support me here: Tumblr / Twitter / Patreon / Instagram 

@maxismatchccworld @sssvitlanz @mmfinds @s4library

New posepack: Spellcasters

A while ago I started making these poses for a character of mine, although he didn’t need them in the end (which is why there will, at some point, be a version of these with a walking stick instead). BUT it got me thinking that there aren’t many (any?) magic poses for spellcasters who use wheelchairs, so I finally got round to finishing it up.

The first four poses have four different emotions (neutral, angry, sad, happy - just basic stuff) and then the rest are just some random ones that I felt like doing.

You will need: - Windkeepers Modern Wheelchair by @teabaker  - Book by @inabadromance for pose 7

TOU: please don’t steal, redistribute, put behind a paywall, or alter (beyond basic tweaking) in renders thank yooouuu. These are free my dudes, play nicely.

Download here (CurseForge) or alternative download here (SFS) Like my poses? You can now buy me a coffee! 

I’d love to see what you do with them so feel free to tag me here, on Twitter, or Instagram.

@ts4-poses

River Monsters

Prints